Disulfiram
Treatment for Cocaine use disorders
Typical Dosage: 125-500mg daily
Effectiveness
55%
Safety Score
55%
Clinical Trials
40
Participants
3K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
125-500mg daily
Time to Effect
1-2 weeks
Treatment Duration
6-12 months
Evidence Quality
MODERATENumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
100(Treat 100 patients to see 1 additional serious adverse event)
Confidence Score
65%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$800
Monitoring:$800
Side Effect Mgmt:$100
Total Annual:$1,700
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEICER
$100,000/QALY
QALYs Gained
0.15
Outcome-Based Costs
Cost per Responder
$3,778
Cost per Remission
$6,800
Disulfiram Outcomes
for Cocaine use disorders
Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+45%
Remission Rate
+25%
Common Side Effects
Headache
+15%
Fatigue/drowsiness
+10%
Metallic or garlic taste
+10%
Hepatotoxicity (elevated liver enzymes)
+3%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov