Condition

Coal workers pneumoconiosis

Clinical trials and treatment information for Coal workers pneumoconiosis

46K
People Affected
5
Active Trials
463
New Cases/Year
2,580
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Smoking Cessation (Behavioral Therapy + Pharmacotherapy)
90% Effectiveness• 95% Confidence• 80% Safety• 500 trials• 200K participants
HIGH EvidenceExcellent ValueDose: Varenicline 1mg BID or Bupropion 150mg BID, with counseling
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
80
DangerousModerateSafe

Time to Effect

Immediate cessation, long-term benefits over years

Duration

3-6 months (pharmacotherapy), ongoing behavioral support

Response Rate

25%

Remission Rate

%

Number Needed to Treat (NNT)

8

Common Side Effects:

Nausea: 15%
Insomnia: 10%
Headache: 8%

Annual Cost of Care

Drug Cost

$500

Monitoring

$200

Side Effects

$20

Total Annual

$720

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.2

ICER

$3,600/QALY

Cost per Responder

$2,880

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+25%
Common Side Effects
Nausea
+15%
Insomnia
+10%
Headache
+8%

Clinical Trial Phases:

Phase 4
2
Oxygen Therapy
80% Effectiveness• 90% Confidence• 90% Safety• 100 trials• 50K participants
HIGH EvidenceExcellent ValueDose: 1-5 L/min continuous or nocturnal
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
90
DangerousModerateSafe

Time to Effect

Immediate (for oxygenation), long-term (for survival)

Duration

Lifetime (if chronic hypoxemia)

Response Rate

90%

Remission Rate

%

Number Needed to Treat (NNT)

3

Common Side Effects:

Nasal irritation: 10%
Skin breakdown: 5%
Fire risk: 1%

Annual Cost of Care

Drug Cost

$1,000

Monitoring

$400

Side Effects

$20

Total Annual

$1,420

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.8

ICER

$1,775/QALY

Cost per Responder

$1,578

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+90%
Common Side Effects
Nasal irritation
+10%
Skin breakdown
+5%
Fire risk
+1%

Clinical Trial Phases:

Phase 4
3
Pulmonary Rehabilitation
80% Effectiveness• 90% Confidence• 95% Safety• 200 trials• 75K participants
HIGH EvidenceExcellent ValueDose: 2-3 sessions/week for 8-12 weeks
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe

Time to Effect

Weeks to months

Duration

8-12 weeks initial program, then maintenance

Response Rate

70%

Remission Rate

%

Common Side Effects:

Musculoskeletal soreness: 5%
Fatigue: 3%

Annual Cost of Care

Drug Cost

$0

Monitoring

$200

Side Effects

$10

Total Annual

$2,000

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.35

ICER

$5,714/QALY

Cost per Responder

$2,857

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+70%
Common Side Effects
Musculoskeletal soreness
+5%
Fatigue
+3%

Clinical Trial Phases:

Phase 4
4
Vaccinations (Influenza & Pneumococcal)
85% Effectiveness• 90% Confidence• 85% Safety• 300 trials• 500K participants
HIGH EvidenceExcellent ValueDose: Standard vaccine doses
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
85
DangerousModerateSafe

Time to Effect

2 weeks (for immunity)

Duration

Annual (influenza), one-time or every 5 years (pneumococcal)

Response Rate

80%

Remission Rate

%

Number Needed to Treat (NNT)

30

Common Side Effects:

Injection site soreness: 20%
Low-grade fever: 5%

Annual Cost of Care

Drug Cost

$100

Monitoring

$600

Side Effects

$5

Total Annual

$705

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.1

ICER

$1,050/QALY

Cost per Responder

$131

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+80%
Common Side Effects
Injection site soreness
+20%
Low-grade fever
+5%

Clinical Trial Phases:

Phase 4
5
Bronchodilators (e.g., LAMA/LABA)
65% Effectiveness• 85% Confidence• 60% Safety• 400 trials• 150K participants
MODERATE EvidenceExcellent ValueDose: Varies by drug (e.g., Tiotropium 18mcg daily)
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

Minutes to weeks depending on agent

Duration

Lifetime (if symptoms persist)

Response Rate

60%

Remission Rate

%

Common Side Effects:

Dry mouth: 10%
Headache: 7%
Tremor: 5%

Annual Cost of Care

Drug Cost

$200

Monitoring

$400

Side Effects

$50

Total Annual

$650

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.2

ICER

$3,250/QALY

Cost per Responder

$1,083

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+60%
Common Side Effects
Dry mouth
+10%
Headache
+7%
Tremor
+5%

Clinical Trial Phases:

Phase 4
6
Corticosteroids (short-term oral)
60% Effectiveness• 85% Confidence• 50% Safety• 150 trials• 30K participants
MODERATE EvidenceExcellent ValueDose: Prednisone 20-40mg daily for 5-14 days
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe

Time to Effect

Hours to days

Duration

5-14 days (for exacerbations)

Response Rate

70%

Remission Rate

%

Common Side Effects:

Insomnia: 25%
Mood changes: 15%
Increased appetite: 10%

Annual Cost of Care

Drug Cost

$50

Monitoring

$200

Side Effects

$50

Total Annual

$300

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.08

ICER

$3,750/QALY

Cost per Responder

$428

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+70%
Common Side Effects
Insomnia
+25%
Mood changes
+15%
Increased appetite
+10%

Clinical Trial Phases:

Phase 4