Topiramate
Treatment for Cluster Headache
Typical Dosage: 100-400 mg/day
Effectiveness
70%
Safety Score
60%
Clinical Trials
1
Participants
550
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
100-400 mg/day
Time to Effect
2-4 weeks
Treatment Duration
Months to years
Evidence Quality
MODERATENumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
12(Treat 12 patients to see 1 additional serious adverse event)
Confidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$300
Monitoring:$400
Side Effect Mgmt:$100
Total Annual:$800
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.15
Outcome-Based Costs
Cost per Responder
$1,778
Topiramate Outcomes
for Cluster Headache
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+45%
Common Side Effects
Paresthesia
+50%
Cognitive slowing
+25%
Fatigue
+15%
Appetite suppression
+15%
Kidney stones
+1.5%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov