High-flow Oxygen
Treatment for Cluster Headache
Typical Dosage: 12-15 L/min via non-rebreather mask
Effectiveness
88%
Safety Score
95%
Clinical Trials
1
Participants
800
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe
Treatment Details
Dosage Range
12-15 L/min via non-rebreather mask
Time to Effect
10-15 minutes
Treatment Duration
15-20 minutes per attack
Evidence Quality
HIGHNumber Needed to Treat (NNT)
2.5(Treat 2.5 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$750
Monitoring:$1,000
Side Effect Mgmt:$20
Total Annual:$1,770
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.15
Outcome-Based Costs
Cost per Responder
$1,027
Prescription Access Economics
Annual Societal Loss per Patient
$-6,130
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$150/year
Time Cost
$50/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$750/year
Potential OTC Price
$600/year
Estimated if OTC available
Early Treatment Benefit
+5000.00 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
MODERATEHigh-flow Oxygen Outcomes
for Cluster Headache
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+75%
Common Side Effects
Dry nasal passages
+8%
Nasal irritation
+3%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
1 active trial recruiting for High-flow Oxygen in Cluster Headache
Pain Biomarker Study
NCT03511846ENROLLING BY INVITATIONPHASE1
371 participants
INTERVENTIONAL
Houston, United States
Started: Mar 21, 2018