Dapagliflozin (SGLT2 Inhibitor)
Treatment for Chronic kidney disease due to glomerulonephritis
Typical Dosage: 10 mg once daily
Effectiveness
82%
Safety Score
65%
Clinical Trials
50
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanideβ οΈ
Methπ
Cigarettesπ¬
Chemoβ’οΈ
AlcoholπΊ
Morphineπ
Antibioticsπ
Tylenolπ
Exerciseπ
Waterπ§
65
DangerousModerateSafe
Treatment Details
Dosage Range
10 mg once daily
Time to Effect
2-3 months for kidney/CV benefits
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
22(Treat 22 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
75(Treat 75 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$5,000
Monitoring:$200
Side Effect Mgmt:$100
Total Annual:$5,300
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$25,000/QALY
QALYs Gained
1.4
Outcome-Based Costs
Cost per Responder
$6,235
Comparison vs RAS inhibitor alone
Cost Difference
+$5,300/year
More expensive
QALY Difference
+1.40 QALYs
Better outcomes
Dominance
No dominance
Dapagliflozin (SGLT2 Inhibitor) Outcomes
for Chronic kidney disease due to glomerulonephritis
Efficacy Outcomes
Overall Effectiveness
+82%
Response Rate
+85%
Common Side Effects
Genital mycotic infections
+7%
Urinary tract infections
+3%
Volume depletion/hypotension
+1.5%
Euglycemic DKA
+0.05%
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov