Condition

Chronic kidney disease due to glomerulonephritis

Clinical trials and treatment information for Chronic kidney disease due to glomerulonephritis

10.7M
People Affected
150
Active Trials
215K
New Cases/Year
194K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Lisinopril (ACE Inhibitor)
85% Effectivenessβ€’ 95% Confidenceβ€’ 70% Safetyβ€’ 500 trialsβ€’ 200K participants
HIGH EvidenceExcellent ValueDose: 5-40 mg once daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
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Chemo☒️
Alcohol🍺
MorphineπŸ’Š
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70
DangerousModerateSafe

Time to Effect

1-3 months for kidney protection

Duration

lifetime

Response Rate

75%

Remission Rate

%

Number Needed to Treat (NNT)

12

Number Needed to Harm (NNH)

250

Common Side Effects:

Cough: 15%
Hyperkalemia: 7%
Hypotension/Dizziness: 3%
Angioedema: 0.3%

Annual Cost of Care

Drug Cost

$20

Monitoring

$200

Side Effects

$50

Total Annual

$270

Cost-Effectiveness

EXCELLENT

QALYs Gained

1

ICER

$15,000/QALY

Cost per Responder

$360

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+75%
Common Side Effects
Cough
+15%
Hyperkalemia
+7%
Hypotension/Dizziness
+3%

Clinical Trial Phases:

Phase 4
2
Dapagliflozin (SGLT2 Inhibitor)
82% Effectivenessβ€’ 95% Confidenceβ€’ 65% Safetyβ€’ 50 trialsβ€’ 50K participants
HIGH EvidenceExcellent ValueDose: 10 mg once daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
65
DangerousModerateSafe

Time to Effect

2-3 months for kidney/CV benefits

Duration

lifetime

Response Rate

85%

Remission Rate

%

Number Needed to Treat (NNT)

22

Number Needed to Harm (NNH)

75

Common Side Effects:

Genital mycotic infections: 7%
Urinary tract infections: 3%
Volume depletion/hypotension: 1.5%
Euglycemic DKA: 0.05%

Annual Cost of Care

Drug Cost

$5,000

Monitoring

$200

Side Effects

$100

Total Annual

$5,300

Cost-Effectiveness

EXCELLENT

QALYs Gained

1.4

ICER

$25,000/QALY

Cost per Responder

$6,235

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+82%
Response Rate
+85%
Common Side Effects
Genital mycotic infections
+7%
Urinary tract infections
+3%
Volume depletion/hypotension
+1.5%

Clinical Trial Phases:

Phase 4
3
Cyclophosphamide
80% Effectivenessβ€’ 90% Confidenceβ€’ 25% Safetyβ€’ 150 trialsβ€’ 10K participants
HIGH EvidenceExcellent ValueDose: 0.5-1 g/mΒ² IV monthly pulses OR 1-2 mg/kg/day orally
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
25
DangerousModerateSafe

Time to Effect

2-6 weeks

Duration

3-6 months (induction)

Response Rate

80%

Remission Rate

60%

Number Needed to Treat (NNT)

3

Number Needed to Harm (NNH)

8

Common Side Effects:

Bone marrow suppression: 65%
Infections: 30%
Hemorrhagic cystitis: 10%
Infertility: 20%
Nausea/vomiting: 45%

Annual Cost of Care

Drug Cost

$1,500

Monitoring

$2,000

Side Effects

$3,000

Total Annual

$6,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

2.2

ICER

$30,000/QALY

Cost per Remission

$10,833

Cost per Responder

$8,125

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+80%
Remission Rate
+60%
Common Side Effects
Bone marrow suppression
+65%
Infections
+30%
Hemorrhagic cystitis
+10%

Clinical Trial Phases:

Phase 4
4
Mycophenolate Mofetil (MMF)
78% Effectivenessβ€’ 90% Confidenceβ€’ 35% Safetyβ€’ 100 trialsβ€’ 15K participants
HIGH EvidenceGood ValueDose: 1-2 g orally twice daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
35
DangerousModerateSafe

Time to Effect

1-3 months

Duration

1-3 years or more

Response Rate

68%

Remission Rate

40%

Number Needed to Treat (NNT)

5

Number Needed to Harm (NNH)

15

Common Side Effects:

Gastrointestinal (diarrhea, nausea): 30%
Leukopenia/anemia: 15%
Infections: 15%

Annual Cost of Care

Drug Cost

$3,000

Monitoring

$800

Side Effects

$700

Total Annual

$4,500

Cost-Effectiveness

GOOD

QALYs Gained

1.4

ICER

$80,000/QALY

Cost per Remission

$11,250

Cost per Responder

$6,618

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+78%
Response Rate
+68%
Remission Rate
+40%
Common Side Effects
Gastrointestinal (diarrhea, nausea)
+30%
Leukopenia/anemia
+15%
Infections
+15%

Clinical Trial Phases:

Phase 4
5
Rituximab
78% Effectivenessβ€’ 85% Confidenceβ€’ 35% Safetyβ€’ 80 trialsβ€’ 8K participants
HIGH EvidenceModerate ValueDose: 375 mg/mΒ² IV weekly for 4 weeks OR 1000 mg IV twice 2 weeks apart
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
35
DangerousModerateSafe

Time to Effect

1-3 months

Duration

Induction, then maintenance every 6-12 months

Response Rate

78%

Remission Rate

60%

Number Needed to Treat (NNT)

4

Number Needed to Harm (NNH)

35

Common Side Effects:

Infusion reactions: 25%
Infections: 15%
Hypogammaglobulinemia: 7%

Annual Cost of Care

Drug Cost

$15,000

Monitoring

$800

Side Effects

$500

Total Annual

$16,300

Cost-Effectiveness

MODERATE

QALYs Gained

1.7

ICER

$120,000/QALY

Cost per Remission

$27,167

Cost per Responder

$20,897

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+78%
Response Rate
+78%
Remission Rate
+60%
Common Side Effects
Infusion reactions
+25%
Infections
+15%
Hypogammaglobulinemia
+7%

Clinical Trial Phases:

Phase 3Phase 4
6
Prednisone (Corticosteroid)
75% Effectivenessβ€’ 90% Confidenceβ€’ 50% Safetyβ€’ 200 trialsβ€’ 20K participants
HIGH EvidenceGood ValueDose: 0.5-1 mg/kg/day (initial), tapered
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
50
DangerousModerateSafe

Time to Effect

days-weeks for anti-inflammatory effects

Duration

3-6 months (induction), then taper

Response Rate

70%

Remission Rate

50%

Number Needed to Treat (NNT)

4

Number Needed to Harm (NNH)

8

Common Side Effects:

Weight gain/fluid retention: 60%
Hyperglycemia/diabetes: 30%
Hypertension: 20%
Insomnia/mood changes: 15%
Osteoporosis (long-term): 15%
Infections: 10%

Annual Cost of Care

Drug Cost

$50

Monitoring

$500

Side Effects

$1,000

Total Annual

$1,550

Cost-Effectiveness

GOOD

QALYs Gained

1.2

ICER

$60,000/QALY

Cost per Remission

$3,100

Cost per Responder

$2,214

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+70%
Remission Rate
+50%
Common Side Effects
Weight gain/fluid retention
+60%
Hyperglycemia/diabetes
+30%
Hypertension
+20%

Clinical Trial Phases:

Phase 4