Condition

Cellulitis

Clinical trials and treatment information for Cellulitis

2.5M
People Affected
50
Active Trials
50M
New Cases/Year
29K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Cephalexin
88% Effectiveness• 90% Confidence• 70% Safety• 7 trials• 50K participants
HIGH EvidenceExcellent ValueDose: 250-500mg orally every 6-12 hours
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
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Chemo☢️
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70
DangerousModerateSafe

Time to Effect

1-2 days

Duration

7 days

Response Rate

90%

Remission Rate

85%

Common Side Effects:

Nausea: 5%
Diarrhea: 8%
Vomiting: 2%
Rash: 1%

Annual Cost of Care

Drug Cost

$15

Monitoring

$125

Side Effects

$10

Total Annual

$150

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.05

Cost per Remission

$176.47

Cost per Responder

$166.67

Treatment Outcomes
Primary Outcomes
Cellulitis Clinical Signs Score (Erythema, Swelling, Warmth)9/12 (higher score indicates more severe signs)
-70% (-6.3 points)
Pain Numeric Rating Scale (NRS)7/10
-75% (-5.25 points)
Body Temperature38.5 0C
-3.89% (-1.5 0C)
Secondary Benefits
C-Reactive Protein (CRP)80 mg/L
-85% (-68 mg/L)
ADL Function Score60/100 (lower score indicates more difficulty)
+25% (+15 points)
EQ-5D-5L Health State Index0.5 (on a 0-1 scale, lower is worse)
+40% (+0.2 points)
Common Side Effects
Nausea
+5%
Diarrhea
+8%
Vomiting
+2%

Clinical Trial Phases:

Phase 4
2
Amoxicillin-Clavulanate
88% Effectiveness• 90% Confidence• 70% Safety• 3 trials• 45K participants
HIGH EvidenceExcellent ValueDose: 500mg/125mg orally every 8 hours or 875mg/125mg orally every 12 hours
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-2 days

Duration

7 days

Response Rate

90%

Remission Rate

85%

Common Side Effects:

Diarrhea: 12%
Nausea: 7%
Abdominal pain: 3%
Rash: 1%

Annual Cost of Care

Drug Cost

$25

Monitoring

$125

Side Effects

$20

Total Annual

$170

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.05

Cost per Remission

$200

Cost per Responder

$188.89

Treatment Outcomes
Primary Outcomes
Area of Erythema150 cm^2
-80% (-120 cm^2)
Pain Severity (VAS)VAS score: 7/10
-70% (-4.9 points on VAS)
Affected Limb Circumference3 cm increase from unaffected limb
-85% (-2.55 cm)
C-reactive Protein (CRP)100 mg/L
-80% (-80 mg/L)
Secondary Benefits
Quality of Life (SF-36 Physical Functioning)SF-36 PF score: 40/100
+25% (+10 points)
Systemic Symptom Score (e.g., malaise, chills)Severity score: 6/10
-60% (-3.6 points)
White Blood Cell Count (WBC)15 x 10^9/L
-40% (-6 x 10^9/L)
Common Side Effects
Diarrhea
+12%
Nausea
+7%
Abdominal pain
+3%

Clinical Trial Phases:

Phase 4
3
Trimethoprim-Sulfamethoxazole
88% Effectiveness• 90% Confidence• 65% Safety• 10 trials• 40K participants
HIGH EvidenceExcellent ValueDose: 160mg TMP/800mg SMX (DS tablet) orally twice daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

1-2 days

Duration

7 days

Response Rate

90%

Remission Rate

85%

Common Side Effects:

Nausea: 7%
Vomiting: 7%
Rash: 4%
Photosensitivity: 7%

Annual Cost of Care

Drug Cost

$15

Monitoring

$125

Side Effects

$30

Total Annual

$170

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.05

Cost per Remission

$200

Cost per Responder

$188.89

Treatment Outcomes
Primary Outcomes
Cellulitis Lesion Area100 cm²
-75% (-75 cm²)
Pain Intensity (NRS 0-10)7/10
-71.4% (-5 points)
Erythema Severity Score (0-3 scale)2/3
-66.7% (-1.3 points)
C-Reactive Protein (CRP)50 mg/L
-80% (-40 mg/L)
Secondary Benefits
Hospitalization Duration5 days
-40% (-2 days)
Dermatology Life Quality Index (DLQI)18 points (severe impact)
-66.7% (-12 points)
Systemic Symptoms Score (0-5 scale)4/5
-75% (-3 points)
Common Side Effects
Nausea
+7%
Vomiting
+7%
Rash
+4%

Clinical Trial Phases:

Phase 4
4
Doxycycline
85% Effectiveness• 88% Confidence• 70% Safety• 2 trials• 40K participants
HIGH EvidenceExcellent ValueDose: 100mg orally twice daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-2 days

Duration

7 days

Response Rate

85%

Remission Rate

80%

Common Side Effects:

Photosensitivity: 15%
Nausea: 7%
Vomiting: 7%
Diarrhea: 7%

Annual Cost of Care

Drug Cost

$15

Monitoring

$125

Side Effects

$15

Total Annual

$155

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.05

Cost per Remission

$193.75

Cost per Responder

$182.35

Treatment Outcomes
Primary Outcomes
Erythema Severity3.0/4 (on a 0-4 scale, 4=severe erythema)
-65% (-1.95 points)
Localized Pain Intensity7/10 (on a VAS 0-10 scale, 10=worst pain)
-60% (-4.2 points)
Local Swelling/Edema Severity2.8/4 (on a 0-4 scale, 4=severe swelling)
-55% (-1.54 points)
Secondary Benefits
C-Reactive Protein (CRP)80 mg/L
-75% (-60 mg/L)
SF-36 Physical Component Summary (PCS)35 points (on a 0-100 scale, lower indicates worse physical health)
+20% (+7 points)
Functional Impairment Score5/10 (on a 0-10 scale, 10=complete impairment)
-40% (-2.0 points)
Common Side Effects
Photosensitivity
+15%
Nausea
+7%
Vomiting
+7%

Clinical Trial Phases:

Phase 4
5
Clindamycin
85% Effectiveness• 88% Confidence• 65% Safety• 8 trials• 35K participants
HIGH EvidenceExcellent ValueDose: 300-450mg orally every 6-8 hours
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

1-2 days

Duration

7 days

Response Rate

85%

Remission Rate

80%

Common Side Effects:

Diarrhea: 15%
Nausea: 7%
Abdominal pain: 7%
Rash: 1%

Annual Cost of Care

Drug Cost

$25

Monitoring

$125

Side Effects

$50

Total Annual

$200

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.05

Cost per Remission

$250

Cost per Responder

$235.29

Treatment Outcomes
Primary Outcomes
Area of Cellulitis (Erythema)100 cm²
-80% (-80 cm²)
Pain Intensity (NRS)7/10 on Numeric Rating Scale
-71.4% (-5 points on NRS)
Local Edema (Affected Limb Circumference)32 cm
-6.25% (-2 cm)
Secondary Benefits
C-reactive Protein (CRP)80 mg/L
-87.5% (-70 mg/L)
SF-36 Physical Functioning Score50 points (out of 100)
+30% (+15 points)
Body Temperature38.5 °C
-3.89% (-1.5 °C)
Common Side Effects
Diarrhea
+15%
Nausea
+7%
Abdominal pain
+7%

Clinical Trial Phases:

Phase 4