Lamotrigine
Treatment for Bipolar Disorder
Typical Dosage: 100-400mg daily
Effectiveness
80%
Safety Score
60%
Clinical Trials
65
Participants
30K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
100-400mg daily
Time to Effect
8-12 weeks (after titration)
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
10(Treat 10 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
1000(Treat 1000 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$800
Side Effect Mgmt:$100
Total Annual:$1,100
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$40,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$2,200
Cost per Remission
$3,666.7
Comparison vs Lithium
Cost Difference
$-200/year
Less expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$450
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$600/year
Time Cost
$120/year
Travel + wait time
Insurance Admin Cost
$80/year
Prior auth, claims
Rx Price
$200/year
Potential OTC Price
$50/year
Estimated if OTC available
Early Treatment Benefit
+0.20 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
LOWLamotrigine Outcomes
for Bipolar Disorder
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+50%
Remission Rate
+30%
Common Side Effects
Headache
+25%
Nausea
+15%
Dizziness
+17%
Rash (benign)
+10%
Stevens-Johnson Syndrome (SJS)/TEN
+0.1%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
19 completed trials for Lamotrigine in Bipolar Disorder
A Clinical Evaluation Of BW430C (Lamotrigine) In Bipolar I Disorder- Long-term Extension Of Study SCA104779 (NCT00550407) -
NCT00566020COMPLETEDPHASE3
92 participants
INTERVENTIONAL
Aichi, Japan +51 more
Started: May 1, 2008
Pregnant Women Taking Lamictal for Bipolar Disorder
NCT01996293COMPLETED
30 participants
OBSERVATIONAL
Chicago, United States
Started: Sep 1, 2013
Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?
NCT02081287COMPLETEDPHASE1
8 participants
INTERVENTIONAL
San Diego, United States
Started: May 1, 2014
Lamotrigine Monotherapy in Pediatric Bipolar Disorder
NCT00176228COMPLETEDPHASE2
48 participants
INTERVENTIONAL
Chicago, United States
Started: Feb 1, 2004
Lamictal Bipolar Observational Study
NCT00460226COMPLETED
238 participants
OBSERVATIONAL
Started: Mar 1, 2007
An Evaluation Of BW430C (Lamotrigine) Versus Placebo In The Prevention Of Mood Episodes In Bipolar I Disorder Patients
NCT00550407COMPLETEDPHASE3
215 participants
INTERVENTIONAL
Aichi, Japan +59 more
Started: Nov 1, 2007
Pharmacokinetics, Safety and Tolerability of Repeat Dosing Lamotrigine in Healthy Chinese Subjects
NCT02513654COMPLETEDPHASE1
16 participants
INTERVENTIONAL
Shanghai, China
Started: Sep 6, 2015
An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder
NCT00360126COMPLETEDPHASE4
11 participants
INTERVENTIONAL
Greenwich, Australia +2 more
Started: Oct 1, 2005
Lamictal as Add-on Treatment for Bipolar I Disorder in Pediatric Patients
NCT00723450COMPLETEDPHASE3
301 participants
INTERVENTIONAL
Dothan, United States +45 more
Started: Jul 1, 2008
Lamictal As Add on Treatment in Mixed States of Bipolar Disorder
NCT00223509COMPLETEDPHASE4
28 participants
INTERVENTIONAL
San Antonio, United States +1 more
Started: Aug 1, 2005
Bipolar Study in Adults at Least 18 Years of Age
NCT00067938COMPLETEDPHASE4
1.2K participants
INTERVENTIONAL
Albertville, United States +307 more
Started: Aug 1, 2003
A Study To Investigate The Antidepressant Effect Of Lamotrigine In Patients With Bipolar Disorder Using Lithium
NCT00224510COMPLETEDPHASE3
120 participants
INTERVENTIONAL
Alkmaar, Netherlands +30 more
Started: Aug 1, 2002
Olanzapine Compared to Lamotrigine in the Prevention of Depressive Episode in the Patients With Bipolar Disorder
NCT01864551COMPLETEDPHASE4
60 participants
INTERVENTIONAL
Taipei, Taiwan
Started: Aug 1, 2008
A Phase IV Study of the Safety and Efficacy of Aripiprazole in Combination With Lamotrigine in the Long-Term Maintenance Treatment of Patients With Bipolar I Disorder With A Recent Manic or Mixed Episode
NCT00277212COMPLETEDPHASE4
1.17K participants
INTERVENTIONAL
Birmingham, United States +65 more
Started: Dec 1, 2005
Lamotrigine for the Treatment of Mania in Youth Ages 6-17 With Bipolar Disorder
NCT00181844COMPLETEDPHASE4
51 participants
INTERVENTIONAL
Cambridge, United States
Started: Jan 1, 2005
Lamotrigine Phase III Study in Bipolar I Disorder
NCT01602510COMPLETEDPHASE3
265 participants
INTERVENTIONAL
Guangzhou, China +20 more
Started: Aug 1, 2012
Bipolar Disorder Study for Men and Women
NCT00056277COMPLETEDPHASE3
150 participants
INTERVENTIONAL
Beverly Hills, United States +19 more
Started: Feb 27, 2003
Lamotrigine for Symptoms of Geriatric Bipolar Depression
NCT00621842COMPLETEDPHASE3
57 participants
INTERVENTIONAL
White Plains, United States +4 more
Started: Jan 1, 2008
Special Drug Use Investigation for LAMICTAL Bipolar
NCT01428518COMPLETED
1.04K participants
OBSERVATIONAL
Started: Nov 1, 2011
Showing 20 of 65 total trials