Condition

Ascariasis

Clinical trials and treatment information for Ascariasis

293.8M
People Affected
60
Active Trials
800M
New Cases/Year
3,473
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Albendazole
95% Effectiveness• 95% Confidence• 70% Safety• 8 trials• 2M participants
HIGH EvidenceExcellent ValueDose: 400 mg oral single dose
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-3 days

Duration

Single dose

Response Rate

98%

Remission Rate

95%

Common Side Effects:

Abdominal pain: 10%
Nausea/Vomiting: 8%
Headache: 5%
Dizziness: 3%

Annual Cost of Care

Drug Cost

$10

Monitoring

$600

Side Effects

$0

Total Annual

$610

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.05

Cost per Remission

$10.53

Cost per Responder

$10.2

Treatment Outcomes
Primary Outcomes
Ascaris lumbricoides Eggs per Gram of Feces (EPG)15,000 EPG
-95% (-14,250 EPG)
Ascaris Stool Microscopy Positivity Rate100%
-90% (-90% (e.g., from 100% to 10% positivity))
Abdominal Pain Severity (on a 0-10 Numerical Rating Scale)6/10
-60% (-3.6 points)
Secondary Benefits
Weight in children (kg)20 kg (for a child with growth faltering)
+5% (+1 kg (over 3-6 months))
Pediatric Quality of Life Inventory (PedsQL) Total Score (0-100 scale)65/100
+12% (+7.8 points)
School Absenteeism Rate15% absence rate per month
-30% (-4.5% (reduction from 15% to 10.5% absence rate))
Common Side Effects
Abdominal pain
+10%
Nausea/Vomiting
+8%
Headache
+5%

Clinical Trial Phases:

Phase 4
2
Ivermectin
95% Effectiveness• 90% Confidence• 70% Safety• 4 trials• 1.5M participants
HIGH EvidenceExcellent ValueDose: 150-200 mcg/kg oral single dose
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-3 days

Duration

Single dose

Response Rate

98%

Remission Rate

95%

Common Side Effects:

Dizziness: 5%
Nausea: 4%
Abdominal pain: 3%

Annual Cost of Care

Drug Cost

$30

Monitoring

$600

Side Effects

$0

Total Annual

$630

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.06

Cost per Remission

$31.58

Cost per Responder

$30.61

Treatment Outcomes
Primary Outcomes
Ascaris Cure Rate (based on negative stool microscopy)0% cured (100% infected population)
+95% (+95 percentage points (from 0% to 95% cured))
Ascaris Egg Reduction Rate (ERR)Mean Ascaris EPG: 6500 eggs/gram
-98% (-6370 eggs/gram (from 6500 to 130 eggs/gram))
Reduction in Ascaris Infection PrevalenceAscaris infection prevalence: 70%
-90% (-63 percentage points (from 70% to 7%))
Secondary Benefits
Weight-for-Age Z-score in childrenMean Z-score: -1.8 SD (indicating moderate underweight)
+22.2% (+0.4 SD (e.g., from -1.8 to -1.4 SD))
Hemoglobin Concentration10.5 g/dL (indicating mild anemia)
+5.7% (+0.6 g/dL (e.g., from 10.5 to 11.1 g/dL))
Frequency of Abdominal Pain (episodes/week)5 episodes/week (moderate pain)
-70% (-3.5 episodes/week (from 5 to 1.5 episodes/week))
Common Side Effects
Dizziness
+5%
Nausea
+4%
Abdominal pain
+3%

Clinical Trial Phases:

Phase 4
3
Mebendazole
93% Effectiveness• 90% Confidence• 70% Safety• 1200 trials• 1.8M participants
HIGH EvidenceExcellent ValueDose: 500 mg oral single dose or 100 mg twice daily for 3 days
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-3 days

Duration

Single dose or 3 days

Response Rate

95%

Remission Rate

90%

Common Side Effects:

Abdominal pain: 8%
Diarrhea: 6%
Headache: 4%

Annual Cost of Care

Drug Cost

$15

Monitoring

$600

Side Effects

$0

Total Annual

$615

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.05

Cost per Remission

$16.67

Cost per Responder

$15.79

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+93%
Response Rate
+95%
Remission Rate
+90%
Common Side Effects
Abdominal pain
+8%
Diarrhea
+6%
Headache
+4%

Clinical Trial Phases:

Phase 4
4
Pyrantel Pamoate
90% Effectiveness• 85% Confidence• 75% Safety• 1 trials• 1M participants
HIGH EvidenceExcellent ValueDose: 11 mg/kg oral single dose (max 1g)
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe

Time to Effect

1-3 days

Duration

Single dose

Response Rate

90%

Remission Rate

85%

Common Side Effects:

Nausea: 7%
Abdominal cramps: 5%
Diarrhea: 3%

Annual Cost of Care

Drug Cost

$20

Monitoring

$600

Side Effects

$0

Total Annual

$620

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.04

Cost per Remission

$23.53

Cost per Responder

$22.22

Treatment Outcomes
Primary Outcomes
Ascaris lumbricoides Egg Reduction RateMean egg count: 15,000 EPG
-90% (-13,500 EPG)
Abdominal Pain SeverityMean VAS score: 6/10
-50% (-3 points on VAS scale)
Hemoglobin Concentration10.5 g/dL
+4.8% (+0.5 g/dL)
Height-for-Age Z-score (in children)Mean Z-score: -1.8
+11.1% (+0.2 Z-score units)
Secondary Benefits
Appetite (Patient-reported visual analog scale)VAS score: 4/10
+25% (+1 point on VAS scale)
Abdominal Symptom Severity (composite score)Composite score: 8/20
-30% (-2.4 points on composite score)
Quality of Life (Child Health Questionnaire PedsQL scale)Overall score: 60/100
+8.3% (+5 points on PedsQL scale)
Common Side Effects
Nausea
+7%
Abdominal cramps
+5%
Diarrhea
+3%

Clinical Trial Phases:

Phase 4