Antibiotic Therapy (for uncomplicated appendicitis)

Treatment for Appendicitis

Typical Dosage: Ertapenem 1g IV daily for 3-5 days, then oral equivalent for 5-7 days; or Cefotaxime 1g IV q8h + Metronidazole 500mg IV q8h for 3-5 days, then oral Amoxicillin-Clavulanate for 5-7 days.

Effectiveness
75%
Safety Score
70%
Clinical Trials
13
Participants
5K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
Ertapenem 1g IV daily for 3-5 days, then oral equivalent for 5-7 days; or Cefotaxime 1g IV q8h + Metronidazole 500mg IV q8h for 3-5 days, then oral Amoxicillin-Clavulanate for 5-7 days.
Time to Effect
24-48 hours for symptom improvement
Treatment Duration
7-14 days (antibiotics), up to 1 year observation for recurrence
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
1.3(Treat 1.3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
4(Treat 4 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$500
Monitoring:$1,000
Side Effect Mgmt:$100
Total Annual:$3,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
ICER
$30,000/QALY
QALYs Gained
-0.02
Outcome-Based Costs
Cost per Responder
$4,667
Cost per Remission
$4,667
Comparison vs Laparoscopic Appendectomy
Cost Difference
$-16,500/year
Less expensive
QALY Difference
-0.02 QALYs
Worse outcomes
Dominance
No dominance
Antibiotic Therapy (for uncomplicated appendicitis) Outcomes

for Appendicitis

Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+75%
Remission Rate
+75%
Common Side Effects
Diarrhea
+10%
Nausea/vomiting
+7%
Allergic reaction
+3%
C. difficile infection
+0.5%
Treatment failure requiring appendectomy
+25%

Sources:

nih.gov
nih.gov
researchgate.net

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
3 active trials recruiting for Antibiotic Therapy (for uncomplicated appendicitis) in Appendicitis

Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis

NCT03236961ACTIVE NOT RECRUITINGNA
View Study
552 participants
INTERVENTIONAL
Turku, Finland
Started: Apr 3, 2017

Antibiotics vs. Placebo in Acute Uncomplicated Appendicitis

NCT03234296ENROLLING BY INVITATIONNA
View Study
147 participants
INTERVENTIONAL
Turku, Finland
Started: Aug 9, 2017

Oral Antibiotic Outpatient Therapy vs. Placebo in the Treatment of Uncomplicated Acute Appendicitis

NCT06210269NOT YET RECRUITINGNA
View Study
498 participants
INTERVENTIONAL
Jyväskylä, Finland +8 more
Started: Jan 1, 2024
Completed Clinical Trials
5 completed trials for Antibiotic Therapy (for uncomplicated appendicitis) in Appendicitis

Appendectomy Versus Conservative Treatment for Uncomplicated Acute Appendicitis

NCT03080103COMPLETED
View Study
300 participants
OBSERVATIONAL
Muravera, Italy +6 more
Started: Jun 1, 2017

Acute Appendicitis: Active Observation With and Without Antibiotics

NCT03985514COMPLETEDPHASE4
View Study
126 participants
INTERVENTIONAL
Gothenburg, Sweden
Started: May 15, 2018

Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis.

NCT04803422COMPLETEDNA
View Study
3.19K participants
INTERVENTIONAL
Slagelse, Denmark +1 more
Started: Apr 1, 2021

Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children

NCT02991937COMPLETEDPHASE4
View Study
39 participants
INTERVENTIONAL
New York, United States
Started: Dec 1, 2016

Pilot Trial of Antibiotics Versus Surgery for Treating Acute Appendicitis

NCT02447224COMPLETEDEARLY_PHASE1
View Study
30 participants
INTERVENTIONAL
Sylmar, United States
Started: Mar 1, 2015