Condition

Amphetamine use disorders

Clinical trials and treatment information for Amphetamine use disorders

9.2M
People Affected
15
Active Trials
275K
New Cases/Year
9,880
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Contingency Management
85% Effectiveness• 90% Confidence• 95% Safety• 1 trials• 5.2K participants
HIGH EvidenceExcellent ValueDose: 2-3 urine drug screens per week, escalating rewards
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
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95
DangerousModerateSafe

Time to Effect

1-2 weeks

Duration

12-24 weeks

Response Rate

65%

Remission Rate

35%

Number Needed to Treat (NNT)

4

Common Side Effects:

Ethical concerns regarding external rewards: 8%

Annual Cost of Care

Drug Cost

$0

Monitoring

$750

Side Effects

$0

Total Annual

$4,750

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.2

ICER

$35,000/QALY

Cost per Remission

$13,571

Cost per Responder

$7,308

Treatment Outcomes
Primary Outcomes
Proportion of Amphetamine-Negative Urine Samples30% negative urine samples
+116.7% (+35 percentage points)
Amphetamine-Free Days per Month10 amphetamine-free days/month
+150% (+15 days/month)
Treatment Retention (weeks)Average 6 weeks
+100% (+6 weeks)
Secondary Benefits
Physical Health Domain Score (WHOQOL-BREF)Score: 60/100
+13.3% (+8 points)
Amphetamine Craving Intensity (VAS score)Visual Analog Scale (VAS) score: 70/100
-35.7% (-25 points)
Days of Employment per Month10 days/month
+50% (+5 days/month)
Common Side Effects
Ethical concerns regarding external rewards
+8%
2
Cognitive Behavioral Therapy (CBT)
75% Effectiveness• 85% Confidence• 95% Safety• 2 trials• 3.2K participants
HIGH EvidenceGood ValueDose: 1-2 sessions per week (60-90 minutes)
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe

Time to Effect

4-8 weeks

Duration

12-20 weeks

Response Rate

50%

Remission Rate

25%

Number Needed to Treat (NNT)

7

Common Side Effects:

Emotional discomfort during sessions: 10%
Temporary increase in anxiety or depression: 3%

Annual Cost of Care

Drug Cost

$0

Monitoring

$400

Side Effects

$0

Total Annual

$400

Cost-Effectiveness

GOOD

QALYs Gained

0.15

ICER

$50,000/QALY

Cost per Remission

$12,000

Cost per Responder

$6,000

Treatment Outcomes
Primary Outcomes
Percentage of Amphetamine-Negative Urine Screens30%
+67% (+20 percentage points (from 30% to 50%))
Percentage of Days Abstinent from Amphetamines25%
+100% (+25 percentage points (from 25% to 50%))
Amphetamine Craving Severity (VAS 0-10)7.0 points
-35% (-2.45 points)
Number of Amphetamine-Free Weeks (over 12-week period)4 weeks
+75% (+3 weeks)
Secondary Benefits
Depression Severity (PHQ-9 score)17/27 (moderate-severe)
-29% (-5 points)
Anxiety Severity (GAD-7 score)14/21 (severe)
-28.5% (-4 points)
Global Assessment of Functioning (GAF score)50/100 (serious impairment)
+16% (+8 points)
Common Side Effects
Emotional discomfort during sessions
+10%
Temporary increase in anxiety or depression
+3%
3
Bupropion Sustained Release
45% Effectiveness• 65% Confidence• 60% Safety• 22 trials• 2.6K participants
MODERATE EvidenceGood ValueDose: 150mg SR twice daily to 200mg SR twice daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

2-4 weeks

Duration

12-24 weeks

Response Rate

35%

Remission Rate

20%

Number Needed to Treat (NNT)

10

Common Side Effects:

Insomnia: 30%
Dry mouth: 18%
Nausea: 12%
Headache: 8%
Seizures: 0.1%

Annual Cost of Care

Drug Cost

$250

Monitoring

$200

Side Effects

$75

Total Annual

$525

Cost-Effectiveness

GOOD

QALYs Gained

0.15

Cost per Remission

$2,625

Cost per Responder

$1,500

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+45%
Response Rate
+35%
Remission Rate
+20%
Common Side Effects
Insomnia
+30%
Dry mouth
+18%
Nausea
+12%

Clinical Trial Phases:

Phase 4
4
Mirtazapine
35% Effectiveness• 50% Confidence• 60% Safety• 8 trials• 700 participants
LOW EvidencePoor ValueDose: 30-45mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

2-4 weeks

Duration

12-24 weeks

Response Rate

30%

Remission Rate

10%

Common Side Effects:

Sedation/Drowsiness: 30%
Increased appetite/Weight gain: 18%
Dry mouth: 15%
Dizziness: 10%

Annual Cost of Care

Drug Cost

$200

Monitoring

$200

Side Effects

$75

Total Annual

$475

Cost-Effectiveness

POOR

QALYs Gained

0.05

Cost per Remission

$4,750

Cost per Responder

$1,583

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+35%
Response Rate
+30%
Remission Rate
+10%
Common Side Effects
Sedation/Drowsiness
+30%
Increased appetite/Weight gain
+18%
Dry mouth
+15%

Clinical Trial Phases:

Phase 4
5
Methylphenidate Extended-Release
30% Effectiveness• 45% Confidence• 45% Safety• 18 trials• 1.6K participants
LOW EvidencePoor ValueDose: 36-72mg ER daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe

Time to Effect

Weeks

Duration

12-24 weeks

Response Rate

25%

Remission Rate

10%

Common Side Effects:

Insomnia: 25%
Anxiety: 20%
Decreased appetite: 15%
Increased heart rate/blood pressure: 8%
Nervousness: 12%

Annual Cost of Care

Drug Cost

$500

Monitoring

$300

Side Effects

$100

Total Annual

$900

Cost-Effectiveness

POOR

QALYs Gained

0.08

Cost per Remission

$9,000

Cost per Responder

$3,600

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+30%
Response Rate
+25%
Remission Rate
+10%
Common Side Effects
Insomnia
+25%
Anxiety
+20%
Decreased appetite
+15%

Clinical Trial Phases:

Phase 4