Condition

Alcoholic cardiomyopathy

Clinical trials and treatment information for Alcoholic cardiomyopathy

528K
People Affected
80
Active Trials
11K
New Cases/Year
64K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Alcohol Abstinence
95% Effectiveness• 95% Confidence• 100% Safety0• 10K participants
HIGH EvidenceExcellent ValueDose: complete cessation
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
100
DangerousModerateSafe

Time to Effect

3-6 months

Duration

lifetime

Response Rate

60%

Remission Rate

25%

Common Side Effects:

Alcohol withdrawal syndrome: 50%
Delirium tremens: 5%

Annual Cost of Care

Drug Cost

$0

Monitoring

$500

Side Effects

$2,000

Total Annual

$2,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

2

Cost per Remission

$10,000

Cost per Responder

$4,167

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+60%
Remission Rate
+25%
Common Side Effects
Alcohol withdrawal syndrome
+50%
Delirium tremens
+5%
2
Dapagliflozin
80% Effectiveness• 95% Confidence• 65% Safety• 20 trials• 20K participants
HIGH EvidenceExcellent ValueDose: 10mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

4-8 weeks

Duration

lifetime

Response Rate

75%

Remission Rate

%

Number Needed to Treat (NNT)

25

Number Needed to Harm (NNH)

15

Common Side Effects:

Genital mycotic infections: 8%
Urinary tract infections: 4%
Hypotension: 3%
Diabetic ketoacidosis (rare): 0.1%

Annual Cost of Care

Drug Cost

$5,500

Monitoring

$300

Side Effects

$100

Total Annual

$5,900

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.5

ICER

$40,000/QALY

Cost per Responder

$7,867

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+75%
Common Side Effects
Genital mycotic infections
+8%
Urinary tract infections
+4%
Hypotension
+3%

Clinical Trial Phases:

Phase 4
3
Carvedilol
75% Effectiveness• 90% Confidence• 70% Safety• 150 trials• 50K participants
HIGH EvidenceExcellent ValueDose: 3.125mg BID, titrated up to 25-50mg BID
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

8-12 weeks

Duration

lifetime

Response Rate

65%

Remission Rate

%

Number Needed to Treat (NNT)

10

Number Needed to Harm (NNH)

30

Common Side Effects:

Fatigue: 15%
Dizziness: 10%
Bradycardia: 5%
Hypotension: 5%

Annual Cost of Care

Drug Cost

$80

Monitoring

$300

Side Effects

$50

Total Annual

$430

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.7

ICER

$20,000/QALY

Cost per Responder

$662

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+65%
Common Side Effects
Fatigue
+15%
Dizziness
+10%
Bradycardia
+5%

Clinical Trial Phases:

Phase 4
4
Lisinopril
75% Effectiveness• 90% Confidence• 70% Safety• 150 trials• 50K participants
HIGH EvidenceExcellent ValueDose: 2.5-5mg daily, titrated to 20-40mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

8-12 weeks

Duration

lifetime

Response Rate

65%

Remission Rate

%

Number Needed to Treat (NNT)

12

Number Needed to Harm (NNH)

50

Common Side Effects:

Cough: 12%
Dizziness: 5%
Hyperkalemia: 3%
Angioedema: 0.3%

Annual Cost of Care

Drug Cost

$80

Monitoring

$350

Side Effects

$50

Total Annual

$480

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.7

ICER

$15,000/QALY

Cost per Responder

$738

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+65%
Common Side Effects
Cough
+12%
Dizziness
+5%
Hyperkalemia
+3%

Clinical Trial Phases:

Phase 4
5
Spironolactone
70% Effectiveness• 85% Confidence• 65% Safety• 1 trials• 15K participants
HIGH EvidenceExcellent ValueDose: 12.5-25mg daily, titrated to 50mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

4-8 weeks

Duration

lifetime

Response Rate

55%

Remission Rate

%

Number Needed to Treat (NNT)

20

Number Needed to Harm (NNH)

15

Common Side Effects:

Hyperkalemia: 12%
Gynecomastia: 7%
Hypotension: 5%

Annual Cost of Care

Drug Cost

$80

Monitoring

$400

Side Effects

$100

Total Annual

$580

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.5

ICER

$10,000/QALY

Cost per Responder

$1,055

Treatment Outcomes
Primary Outcomes
Left Ventricular Ejection Fraction (LVEF)35%
+7.14% (+2.5 percentage points)
NT-proBNP2500 pg/mL
-25% (-625 pg/mL)
Kansas City Cardiomyopathy Questionnaire (KCCQ) Overall Summary ScoreKCCQ-OS score: 45/100
+15.56% (+7 points)
Secondary Benefits
6-Minute Walk Test (6MWT)300 meters
+10% (+30 meters)
Left Ventricular End-Diastolic Volume (LVEDV)180 mL
-7% (-12.6 mL)
Systolic Blood Pressure130 mmHg
-5% (-6.5 mmHg)
Common Side Effects
Hyperkalemia
+12%
Gynecomastia
+7%
Hypotension
+5%

Clinical Trial Phases:

Phase 4
6
Furosemide
60% Effectiveness• 90% Confidence• 65% Safety• 100 trials• 20K participants
HIGH EvidenceGood ValueDose: 20-80mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

immediate (hours)

Duration

as needed/lifetime

Response Rate

85%

Remission Rate

%

Number Needed to Harm (NNH)

8

Common Side Effects:

Electrolyte imbalance (hypokalemia, hyponatremia): 25%
Dizziness: 10%
Hypotension: 10%
Renal dysfunction: 5%

Annual Cost of Care

Drug Cost

$50

Monitoring

$300

Side Effects

$100

Total Annual

$450

Cost-Effectiveness

GOOD

QALYs Gained

0.15

ICER

$30,000/QALY

Cost per Responder

$529

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+85%
Common Side Effects
Electrolyte imbalance (hypokalemia, hyponatremia)
+25%
Dizziness
+10%
Hypotension
+10%

Clinical Trial Phases:

Phase 4