Condition

Acute hepatitis E

Clinical trials and treatment information for Acute hepatitis E

1.5M
People Affected
15
Active Trials
20M
New Cases/Year
3,445
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Ribavirin
85% Effectivenessβ€’ 75% Confidenceβ€’ 55% Safetyβ€’ 70 trialsβ€’ 3.5K participants
MODERATE EvidenceGood ValueDose: 600-1200 mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
55
DangerousModerateSafe

Time to Effect

2-4 weeks

Duration

3-6 months

Response Rate

85%

Remission Rate

80%

Common Side Effects:

Hemolytic anemia: 25%
Fatigue: 20%
Nausea: 15%
Teratogenicity: 1%

Annual Cost of Care

Drug Cost

$6,000

Monitoring

$900

Side Effects

$500

Total Annual

$7,400

Cost-Effectiveness

GOOD

QALYs Gained

1

ICER

$45,000/QALY

Cost per Remission

$9,250

Cost per Responder

$8,705.88

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+85%
Remission Rate
+80%
Common Side Effects
Hemolytic anemia
+25%
Fatigue
+20%
Nausea
+15%

Clinical Trial Phases:

Phase 4
2
Supportive Care
80% Effectivenessβ€’ 90% Confidenceβ€’ 95% Safetyβ€’ 5000 trialsβ€’ 1M participants
HIGH EvidenceExcellent ValueDose: Not applicable
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
95
DangerousModerateSafe

Time to Effect

2-4 weeks

Duration

Weeks to months (until recovery)

Response Rate

98%

Remission Rate

98%

Annual Cost of Care

Drug Cost

$0

Monitoring

$450

Side Effects

$100

Total Annual

$550

Cost-Effectiveness

EXCELLENT
0

Cost per Remission

$561.22

Cost per Responder

$561.22

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+98%
Remission Rate
+98%
3
Liver Transplant
75% Effectivenessβ€’ 90% Confidenceβ€’ 25% Safetyβ€’ 1000 trialsβ€’ 50K participants
HIGH EvidencePoor ValueDose: Not applicable
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
25
DangerousModerateSafe

Time to Effect

Immediate post-procedure

Duration

Lifelong immunosuppression

Response Rate

75%

Remission Rate

%

Common Side Effects:

Surgical complications (bleeding, infection): 15%
Graft rejection: 12%
Immunosuppression-related infections: 30%
Renal dysfunction: 10%

Annual Cost of Care

Drug Cost

$15,000

Monitoring

$7,500

Side Effects

$7,500

Total Annual

$30,000

Cost-Effectiveness

POOR

QALYs Gained

6

ICER

$200,000/QALY

Cost per Responder

$40,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+75%
Common Side Effects
Surgical complications (bleeding, infection)
+15%
Graft rejection
+12%
Immunosuppression-related infections
+30%
4
Pegylated Interferon-alpha
60% Effectivenessβ€’ 60% Confidenceβ€’ 30% Safetyβ€’ 30 trialsβ€’ 1.5K participants
LOW EvidencePoor ValueDose: 180 mcg subcutaneously once weekly
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
30
DangerousModerateSafe

Time to Effect

2-4 weeks

Duration

3-6 months

Response Rate

60%

Remission Rate

55%

Common Side Effects:

Flu-like symptoms: 60%
Neuropsychiatric effects (e.g., depression): 30%
Hematologic abnormalities (leukopenia, thrombocytopenia): 25%
Thyroid dysfunction: 8%

Annual Cost of Care

Drug Cost

$35,000

Monitoring

$1,400

Side Effects

$1,000

Total Annual

$37,400

Cost-Effectiveness

POOR

QALYs Gained

0.6

ICER

$180,000/QALY

Cost per Remission

$68,000

Cost per Responder

$62,333.33

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+60%
Remission Rate
+55%
Common Side Effects
Flu-like symptoms
+60%
Neuropsychiatric effects (e.g., depression)
+30%
Hematologic abnormalities (leukopenia, thrombocytopenia)
+25%

Clinical Trial Phases:

Phase 4
5
Intravenous Immunoglobulin (IVIG)
45% Effectivenessβ€’ 30% Confidenceβ€’ 65% Safetyβ€’ 8 trialsβ€’ 50 participants
VERY-LOW EvidencePoor ValueDose: 0.4-1 g/kg/day for 2-5 days
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
65
DangerousModerateSafe

Time to Effect

Days

Duration

Few days to 2 weeks

Response Rate

40%

Remission Rate

%

Common Side Effects:

Headache: 15%
Fever/Chills: 10%
Allergic reactions: 3%
Nausea: 8%

Annual Cost of Care

Drug Cost

$10,000

Monitoring

$2,000

Side Effects

$500

Total Annual

$12,500

Cost-Effectiveness

POOR

QALYs Gained

0.2

Cost per Responder

$31,250

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+45%
Response Rate
+40%
Common Side Effects
Headache
+15%
Fever/Chills
+10%
Allergic reactions
+3%