Condition

Acute hepatitis A

Clinical trials and treatment information for Acute hepatitis A

12M
People Affected
50
Active Trials
1.5M
New Cases/Year
27K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Supportive Care (Rest, Hydration, Nutrition)
100% Effectivenessβ€’ 100% Confidenceβ€’ 95% Safety00
HIGH EvidenceExcellent ValueDose: Adequate rest, maintain hydration, balanced diet, avoid alcohol and hepatotoxins
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
95
DangerousModerateSafe

Time to Effect

Immediate symptom relief, full recovery over weeks to months

Duration

Weeks to months

Response Rate

100%

Remission Rate

99%

Annual Cost of Care

Drug Cost

$0

Monitoring

$200

Side Effects

$0

Total Annual

$200

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.08

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+100%
Response Rate
+100%
Remission Rate
+99%
2
Hepatitis A Vaccine (Post-exposure prophylaxis)
95% Effectivenessβ€’ 95% Confidenceβ€’ 88% Safetyβ€’ 200 trialsβ€’ 5M participants
HIGH EvidenceExcellent ValueDose: 0.5mL or 1mL IM, based on age/manufacturer
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
88
DangerousModerateSafe

Time to Effect

Protection within 2-4 weeks after first dose, some immediate effect as PEP

Duration

Single dose for PEP, two doses over 6-12 months for long-term immunity

Response Rate

95%

Remission Rate

%

Number Needed to Treat (NNT)

10

Number Needed to Harm (NNH)

100000

Common Side Effects:

Injection site pain: 50%
Headache: 15%
Low-grade fever: 10%

Annual Cost of Care

Drug Cost

$50

Monitoring

$800

Side Effects

$0

Total Annual

$850

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.08

ICER

$40,000/QALY

Cost per Responder

$52.63

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Common Side Effects
Injection site pain
+50%
Headache
+15%
Low-grade fever
+10%

Clinical Trial Phases:

Phase 4
3
Immunoglobulin (Post-exposure prophylaxis)
85% Effectivenessβ€’ 90% Confidenceβ€’ 78% Safetyβ€’ 100 trialsβ€’ 300K participants
HIGH EvidenceGood ValueDose: 0.02 mL/kg IM for typical exposures
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
78
DangerousModerateSafe

Time to Effect

Immediate passive immunity

Duration

Single dose, short-term protection (weeks-months)

Response Rate

85%

Remission Rate

%

Number Needed to Treat (NNT)

15

Number Needed to Harm (NNH)

1000

Common Side Effects:

Injection site pain: 30%
Headache: 10%
Malaise: 8%

Annual Cost of Care

Drug Cost

$200

Monitoring

$800

Side Effects

$0

Total Annual

$1,000

Cost-Effectiveness

GOOD

QALYs Gained

0.07

ICER

$75,000/QALY

Cost per Responder

$235.29

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+85%
Common Side Effects
Injection site pain
+30%
Headache
+10%
Malaise
+8%

Clinical Trial Phases:

Phase 4
4
Symptomatic Medications (e.g., Antiemetics, Analgesics)
85% Effectivenessβ€’ 90% Confidenceβ€’ 78% Safetyβ€’ 500 trialsβ€’ 1M participants
HIGH EvidenceExcellent ValueDose: Varies by medication (e.g., Acetaminophen 500-1000mg every 4-6h, Ondansetron 4-8mg every 8h)
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
78
DangerousModerateSafe

Time to Effect

30 minutes to 1 hour

Duration

As needed, typically days to weeks

Response Rate

90%

Remission Rate

%

Number Needed to Treat (NNT)

3

Number Needed to Harm (NNH)

500

Common Side Effects:

Headache: 10%
Constipation: 8%
Nausea: 5%

Annual Cost of Care

Drug Cost

$50

Monitoring

$800

Side Effects

$0

Total Annual

$850

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.01

Cost per Responder

$55.56

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+90%
Common Side Effects
Headache
+10%
Constipation
+8%
Nausea
+5%

Clinical Trial Phases:

Phase 4