Condition

Acute glomerulonephritis

Clinical trials and treatment information for Acute glomerulonephritis

35K
People Affected
50
Active Trials
2M
New Cases/Year
11K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Plasma Exchange
85% Effectiveness• 85% Confidence• 40% Safety• 1 trials• 5K participants
HIGH EvidenceExcellent ValueDose: Typically 5-7 sessions of 1-1.5 plasma volumes exchange
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
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40
DangerousModerateSafe

Time to Effect

Days to 1-2 weeks

Duration

5-10 sessions over 1-2 weeks

Response Rate

75%

Remission Rate

55%

Common Side Effects:

Hypotension: 15%
Allergic reactions: 8%
Catheter-related complications (infection, bleeding): 7%
Coagulopathy: 7%
Electrolyte disturbances: 7%

Annual Cost of Care

Drug Cost

$0

Monitoring

$7,500

Side Effects

$2,000

Total Annual

$9,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

3.5

ICER

$2,714/QALY

Cost per Remission

$17,273

Cost per Responder

$12,667

Treatment Outcomes
Primary Outcomes
Serum Creatinine4.5 mg/dL
-35% (-1.6 mg/dL)
Anti-GBM Antibody TiterAnti-GBM antibody: 150 U/mL
-60% (-90 U/mL)
Estimated Glomerular Filtration Rate (eGFR)15 mL/min/1.73m2
+25% (+3.8 mL/min/1.73m2)
Secondary Benefits
Urine Protein-to-Creatinine Ratio5.0 g/g
-40% (-2.0 g/g)
C-reactive protein (CRP)40 mg/L
-50% (-20 mg/L)
Birmingham Vasculitis Activity Score (BVAS)BVAS score: 18/33
-60% (-10.8 points)
Common Side Effects
Hypotension
+15%
Allergic reactions
+8%
Catheter-related complications (infection, bleeding)
+7%

Clinical Trial Phases:

Phase 4
2
Cyclophosphamide
80% Effectiveness• 85% Confidence• 30% Safety• 1 trials• 20K participants
HIGH EvidenceExcellent ValueDose: 0.5-1 g/m² IV monthly, or daily oral 1-2 mg/kg
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe

Time to Effect

Weeks to 2 months

Duration

3-6 months induction, then switch to maintenance

Response Rate

80%

Remission Rate

60%

Common Side Effects:

Bone marrow suppression (leukopenia, anemia, thrombocytopenia): 40%
Infections: 25%
Hemorrhagic cystitis: 15%
Infertility: 25%
Nausea, vomiting, alopecia: 35%

Annual Cost of Care

Drug Cost

$1,000

Monitoring

$3,000

Side Effects

$2,000

Total Annual

$6,000

Cost-Effectiveness

EXCELLENT

QALYs Gained

2.5

ICER

$2,400/QALY

Cost per Remission

$10,000

Cost per Responder

$7,500

Treatment Outcomes
Primary Outcomes
24-hour Urine Protein3.5 g/24h
-60% (-2.1 g/24h)
Serum Creatinine2.0 mg/dL
-25% (-0.5 mg/dL)
Estimated Glomerular Filtration Rate (eGFR)45 mL/min/1.73m²
+20% (+9 mL/min/1.73m²)
Hematuria (Red Blood Cells per High Power Field)50 RBCs/HPF
-80% (-40 RBCs/HPF)
Secondary Benefits
Serum Albumin3.0 g/dL
+20% (+0.6 g/dL)
Systolic Blood Pressure145 mmHg
-10% (-14.5 mmHg)
Fatigue Assessment Scale (FACIT-Fatigue)20/52 points
+25% (+5 points)
Common Side Effects
Bone marrow suppression (leukopenia, anemia, thrombocytopenia)
+40%
Infections
+25%
Hemorrhagic cystitis
+15%

Clinical Trial Phases:

Phase 4
3
Lisinopril
80% Effectiveness• 90% Confidence• 70% Safety• 400 trials• 50K participants
HIGH EvidenceExcellent ValueDose: 5-40 mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

Days to 1-2 weeks

Duration

Long-term, often lifetime

Response Rate

75%

Remission Rate

%

Common Side Effects:

Cough: 10%
Dizziness/Hypotension: 7%
Hyperkalemia: 7%
Angioedema: 1%

Annual Cost of Care

Drug Cost

$75

Monitoring

$300

Side Effects

$75

Total Annual

$450

Cost-Effectiveness

EXCELLENT

QALYs Gained

2.5

ICER

$180/QALY

Cost per Responder

$600

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+75%
Common Side Effects
Cough
+10%
Dizziness/Hypotension
+7%
Hyperkalemia
+7%

Clinical Trial Phases:

Phase 4
4
Prednisone
75% Effectiveness• 85% Confidence• 45% Safety• 1 trials• 30K participants
HIGH EvidenceExcellent ValueDose: 30-60 mg daily, tapered
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe

Time to Effect

Days to 1-2 weeks

Duration

Weeks to several months, tapering

Response Rate

70%

Remission Rate

50%

Common Side Effects:

Weight gain: 70%
Fluid retention: 60%
Insomnia: 50%
Increased appetite: 70%
Mood changes: 30%
Hyperglycemia: 25%

Annual Cost of Care

Drug Cost

$200

Monitoring

$750

Side Effects

$750

Total Annual

$1,700

Cost-Effectiveness

EXCELLENT

QALYs Gained

1

ICER

$1,700/QALY

Cost per Remission

$3,400

Cost per Responder

$2,428

Treatment Outcomes
Primary Outcomes
24-hour Urine Protein Excretion2.5 g/day
-60% (-1.5 g/day)
Serum Creatinine2.0 mg/dL
-30% (-0.6 mg/dL)
Urinary Red Blood Cell Count120 RBCs/HPF
-90% (-108 RBCs/HPF)
Blood Pressure145/90 mmHg
-13.8% (-20/10 mmHg)
Secondary Benefits
Serum Albumin3.2 g/dL
+15% (+0.48 g/dL)
Estimated Glomerular Filtration Rate (eGFR)50 mL/min/1.73m²
+25% (+12.5 mL/min/1.73m²)
FACIT-Fatigue Score25/52
+20% (+5 points)
Common Side Effects
Weight gain
+70%
Fluid retention
+60%
Insomnia
+50%

Clinical Trial Phases:

Phase 4
5
Mycophenolate Mofetil
70% Effectiveness• 80% Confidence• 38% Safety• 100 trials• 15K participants
HIGH EvidenceExcellent ValueDose: 1-1.5 g twice daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
38
DangerousModerateSafe

Time to Effect

Weeks to 3 months

Duration

Months to years, often long-term

Response Rate

60%

Remission Rate

40%

Common Side Effects:

GI disturbances (nausea, diarrhea, abdominal pain): 40%
Leukopenia: 18%
Increased risk of infection: 18%
Anemia: 8%
Teratogenic: 100%

Annual Cost of Care

Drug Cost

$2,000

Monitoring

$2,000

Side Effects

$1,500

Total Annual

$5,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

1.8

ICER

$3,056/QALY

Cost per Remission

$13,750

Cost per Responder

$9,167

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+60%
Remission Rate
+40%
Common Side Effects
GI disturbances (nausea, diarrhea, abdominal pain)
+40%
Leukopenia
+18%
Increased risk of infection
+18%

Clinical Trial Phases:

Phase 4