Nitrofurantoin

Treatment for Urinary tract infections and interstitial nephritis

Typical Dosage: 100 mg twice daily

Effectiveness
92%
Safety Score
70%
Clinical Trials
1
Participants
75K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
100 mg twice daily
Time to Effect
1-2 days
Treatment Duration
5-7 days
Evidence Quality
HIGH
Number Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$20
Monitoring:$600
Side Effect Mgmt:$5
Total Annual:$625
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
QALYs Gained
Outcome-Based Costs
Cost per Responder
$28
Cost per Remission
$29
Prescription Access Economics
Annual Societal Loss per Patient
$135
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$150/year
Time Cost
$50/year
Travel + wait time
Insurance Admin Cost
$15/year
Prior auth, claims
Rx Price
$20/year
Potential OTC Price
$8/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOW
Missed Diagnosis Risk
MODERATE
Nitrofurantoin Outcomes

for Urinary tract infections and interstitial nephritis

Efficacy Outcomes
Overall Effectiveness
+92%
Response Rate
+90%
Remission Rate
+85%
Common Side Effects
Nausea
+9%
Headache
+5%
Diarrhea
+5%
Urine discoloration
+100%

Sources:

oup.com
researchgate.net
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
1 completed trial for Nitrofurantoin in Urinary tract infections and interstitial nephritis

A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux

NCT00382343COMPLETEDPHASE4
View Study
96 participants
INTERVENTIONAL
Bologna, Italy +6 more
Started: Nov 1, 1999