Dextromethorphan
Treatment for Upper respiratory infections
Typical Dosage: 10-30mg every 4-8 hours (max 120mg/day)
Effectiveness
65%
Safety Score
75%
Clinical Trials
6
Participants
12K
Comparative Safety Scale(Higher is safer)
Cyanideβ οΈ
Methπ
Cigarettesπ¬
Chemoβ’οΈ
AlcoholπΊ
Morphineπ
Antibioticsπ
Tylenolπ
Exerciseπ
Waterπ§
75
DangerousModerateSafe
Treatment Details
Dosage Range
10-30mg every 4-8 hours (max 120mg/day)
Time to Effect
15-30 minutes
Treatment Duration
As needed, 3-7 days for cough
Evidence Quality
MODERATENumber Needed to Treat (NNT)
9(Treat 9 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
1500(Treat 1500 patients to see 1 additional serious adverse event)
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$10
Monitoring:$600
Side Effect Mgmt:$0
Total Annual:$610
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.003
Outcome-Based Costs
Cost per Responder
$15.38
Dextromethorphan Outcomes
for Upper respiratory infections
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+65%
Common Side Effects
Drowsiness/dizziness
+8%
Nausea
+3%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
5 completed trials for Dextromethorphan in Upper respiratory infections
A Clinical Evidence Study Evaluating Quality of Life Parameters Following Treatment With Robitussin
NCT06716645COMPLETEDPHASE4
244 participants
INTERVENTIONAL
New York, United States
Started: Dec 4, 2024
Effect of Honey and Dextromethorphan on Nocturnal Cough and Sleep
NCT00127686COMPLETEDPHASE1
105 participants
INTERVENTIONAL
Hershey, United States
Started: Sep 1, 2005
To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers
NCT03415243COMPLETEDPHASE1
28 participants
INTERVENTIONAL
Lexington, United States
Started: Mar 1, 2018
The Effect of Paracetamol, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Tablets Compared to Placebo in Subjects Suffering From the Common Cold or Influenza.
NCT02246166COMPLETEDPHASE4
53 participants
INTERVENTIONAL
Shanghai, China +1 more
Started: Jan 1, 2015
A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms
NCT03213353COMPLETEDPHASE1
72 participants
INTERVENTIONAL
Saint Petersburg, Russia
Started: Jul 3, 2017