5-Fluorouracil (topical)
Treatment for Non-melanoma skin cancer (squamous-cell carcinoma)
Typical Dosage: 5% cream, twice daily
Effectiveness
85%
Safety Score
60%
Clinical Trials
2
Participants
30K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
5% cream, twice daily
Time to Effect
2-4 weeks
Treatment Duration
2-4 weeks
Evidence Quality
HIGHConfidence Score
88%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$100
Monitoring:$200
Side Effect Mgmt:$50
Total Annual:$350
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$20,000/QALY
QALYs Gained
0.7
Outcome-Based Costs
Cost per Responder
$412
Cost per Remission
$412
Comparison vs Surgical Excision
Cost Difference
$-1,500/year
Less expensive
QALY Difference
-0.05 QALYs
Worse outcomes
Dominance
No dominance
5-Fluorouracil (topical) Outcomes
for Non-melanoma skin cancer (squamous-cell carcinoma)
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+85%
Remission Rate
+85%
Common Side Effects
Erythema (redness)
+95%
Crusting/erosion
+80%
Pain/burning/soreness
+80%
Edema (swelling)
+60%
Pruritus (itching)
+60%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
1 completed trial for 5-Fluorouracil (topical) in Non-melanoma skin cancer (squamous-cell carcinoma)
CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial
NCT00847912COMPLETEDPHASE4
954 participants
INTERVENTIONAL
Palo Alto, United States +12 more
Started: Jun 26, 2009