Condition

Myocarditis

Clinical trials and treatment information for Myocarditis

505K
People Affected
50
Active Trials
500K
New Cases/Year
32K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Lisinopril (ACE Inhibitor)
85% Effectiveness• 90% Confidence• 70% Safety• 300 trials• 200K participants
HIGH EvidenceExcellent ValueDose: 2.5-40 mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
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Chemo☢️
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Morphine💊
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70
DangerousModerateSafe

Time to Effect

2-4 weeks for full cardiac remodeling benefits

Duration

Lifetime

Response Rate

75%

Remission Rate

%

Number Needed to Treat (NNT)

12

Common Side Effects:

Cough: 15%
Dizziness/Hypotension: 8%
Hyperkalemia: 7%
Renal dysfunction: 2%

Annual Cost of Care

Drug Cost

$100

Monitoring

$600

Side Effects

$75

Total Annual

$775

Cost-Effectiveness

EXCELLENT

QALYs Gained

1.5

Cost per Responder

$1,033

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+75%
Common Side Effects
Cough
+15%
Dizziness/Hypotension
+8%
Hyperkalemia
+7%

Clinical Trial Phases:

Phase 4
2
Metoprolol (Beta-blocker)
85% Effectiveness• 90% Confidence• 70% Safety• 1 trials• 200K participants
HIGH EvidenceExcellent ValueDose: 12.5-200 mg daily (extended-release)
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
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Water💧
70
DangerousModerateSafe

Time to Effect

2-4 weeks for full cardiac remodeling benefits

Duration

Lifetime

Response Rate

75%

Remission Rate

%

Number Needed to Treat (NNT)

12

Common Side Effects:

Bradycardia: 15%
Fatigue: 12%
Dizziness: 10%
Hypotension: 7%

Annual Cost of Care

Drug Cost

$100

Monitoring

$600

Side Effects

$75

Total Annual

$775

Cost-Effectiveness

EXCELLENT

QALYs Gained

1.5

Cost per Responder

$1,033

Treatment Outcomes
Primary Outcomes
Left Ventricular Ejection Fraction35%
+28.57% (+10 percentage points)
NYHA Functional ClassClass III
-33.33% (Improvement by 1 class)
Resting Heart Rate95 bpm
-26.32% (-25 bpm)
High-Sensitivity Troponin T0.5 ng/mL
-80% (-0.4 ng/mL)
Secondary Benefits
6-Minute Walk Test Distance300 meters
+16.67% (+50 meters)
Ventricular Arrhythmia Burden (PVCs/24h)1500 PVCs/24h
-66.67% (-1000 PVCs/24h)
Left Ventricular End-Diastolic Diameter58 mm
-8.62% (-5 mm)
Common Side Effects
Bradycardia
+15%
Fatigue
+12%
Dizziness
+10%

Clinical Trial Phases:

Phase 4
3
Prednisone (Corticosteroid)
75% Effectiveness• 70% Confidence• 45% Safety• 1 trials• 2K participants
MODERATE EvidenceExcellent ValueDose: 0.5-1 mg/kg/day, tapered
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Comparative Safety Scale(Higher is safer)

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Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe

Time to Effect

Days to weeks

Duration

Weeks to months (tapered)

Response Rate

60%

Remission Rate

40%

Common Side Effects:

Hyperglycemia: 30%
Insomnia: 20%
Fluid retention: 15%
Mood changes: 10%
Increased infection risk: 8%

Annual Cost of Care

Drug Cost

$150

Monitoring

$700

Side Effects

$400

Total Annual

$1,250

Cost-Effectiveness

EXCELLENT

QALYs Gained

1

Cost per Remission

$3,125

Cost per Responder

$2,083

Treatment Outcomes
Primary Outcomes
Left Ventricular Ejection Fraction (LVEF)40%
+25% (+10 percentage points)
Cardiac Troponin I1.5 ng/mL
-80% (-1.2 ng/mL)
C-Reactive Protein (CRP)35 mg/L
-85.7% (-30 mg/L)
NYHA Functional ClassNYHA Class III (Score: 3/4)
-33.3% (-1 Class)
Secondary Benefits
N-terminal pro-B-type natriuretic peptide (NT-proBNP)2500 pg/mL
-60% (-1500 pg/mL)
Erythrocyte Sedimentation Rate (ESR)50 mm/hr
-70% (-35 mm/hr)
Kansas City Cardiomyopathy Questionnaire (KCCQ) Overall Summary Score40 points (out of 100)
+37.5% (+15 points)
Common Side Effects
Hyperglycemia
+30%
Insomnia
+20%
Fluid retention
+15%

Clinical Trial Phases:

Phase 4
4
Colchicine
70% Effectiveness• 80% Confidence• 60% Safety• 2 trials• 5K participants
HIGH EvidenceExcellent ValueDose: 0.5 mg once or twice daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

Days to weeks

Duration

3-6 months or longer

Response Rate

75%

Remission Rate

60%

Number Needed to Treat (NNT)

4

Common Side Effects:

Diarrhea: 15%
Nausea/Abdominal cramps: 8%
Myopathy: 1%

Annual Cost of Care

Drug Cost

$200

Monitoring

$300

Side Effects

$50

Total Annual

$550

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.3

ICER

$15,000/QALY

Cost per Remission

$917

Cost per Responder

$733

Treatment Outcomes
Primary Outcomes
hs-CRP18 mg/L
-60% (-10.8 mg/L)
Left Ventricular Ejection Fraction (LVEF)50%
+6% (+3 percentage points)
Myocardial Edema (Cardiac MRI T2 Relaxation Time)65 ms
-15% (-9.75 ms)
Secondary Benefits
Cardiac Symptom Score65/100
-25% (-16.25 points)
6-Minute Walk Test (6MWT) Distance380 meters
+12% (+45.6 meters)
NT-proBNP750 pg/mL
-30% (-225 pg/mL)
Common Side Effects
Diarrhea
+15%
Nausea/Abdominal cramps
+8%
Myopathy
+1%

Clinical Trial Phases:

Phase 4
5
Intravenous Immunoglobulin (IVIG)
60% Effectiveness• 55% Confidence• 60% Safety• 2 trials• 1K participants
LOW EvidencePoor ValueDose: 1-2 g/kg total dose
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

Days to weeks

Duration

2-5 day course

Response Rate

50%

Remission Rate

30%

Common Side Effects:

Headache: 25%
Fever/Chills: 15%
Infusion reactions: 8%
Renal dysfunction: 1%

Annual Cost of Care

Drug Cost

$25,000

Monitoring

$750

Side Effects

$100

Total Annual

$25,850

Cost-Effectiveness

POOR

QALYs Gained

0.7

Cost per Remission

$86,167

Cost per Responder

$51,700

Treatment Outcomes
Primary Outcomes
Left Ventricular Ejection Fraction (LVEF)35%
+28.57% (+10 percentage points)
Cardiac Troponin I0.5 ng/mL
-80% (-0.4 ng/mL)
C-Reactive Protein (CRP)50 mg/L
-80% (-40 mg/L)
NT-proBNP2000 pg/mL
-60% (-1200 pg/mL)
Secondary Benefits
Myocarditis Symptom Score (0-100)60/100
-41.67% (-25 points)
Quality of Life Score (SF-36 Physical Component Summary)30/100
+50% (+15 points)
Global Longitudinal Strain (GLS)-10%
+50% (-5 percentage points)
Common Side Effects
Headache
+25%
Fever/Chills
+15%
Infusion reactions
+8%

Clinical Trial Phases:

Phase 4
6
Azathioprine (Immunosuppressant)
55% Effectiveness• 60% Confidence• 30% Safety• 2 trials• 500 participants
LOW EvidenceExcellent ValueDose: 1-3 mg/kg/day
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe

Time to Effect

Weeks to months

Duration

Months to years

Response Rate

50%

Remission Rate

30%

Common Side Effects:

Nausea/Vomiting: 15%
Bone marrow suppression: 10%
Liver dysfunction: 7%
Increased infection risk: 5%

Annual Cost of Care

Drug Cost

$200

Monitoring

$1,500

Side Effects

$300

Total Annual

$2,000

Cost-Effectiveness

EXCELLENT

QALYs Gained

1

Cost per Remission

$6,667

Cost per Responder

$4,000

Treatment Outcomes
Primary Outcomes
Left Ventricular Ejection Fraction (LVEF)40%
+15% (+6 percentage points)
NYHA Functional ClassificationMean NYHA Class: 2.7
-29.6% (-0.8 NYHA class points)
High-Sensitivity Cardiac Troponin T (hs-cTnT)0.08 ng/mL
-62.5% (-0.05 ng/mL)
C-Reactive Protein (CRP)5.5 mg/L
-72.7% (-4.0 mg/L)
Secondary Benefits
Left Ventricular End-Diastolic Diameter (LVEDD)60 mm
-6.7% (-4 mm)
Kansas City Cardiomyopathy Questionnaire (KCCQ) Overall Summary Score65 points
+12.3% (+8 points)
Hospitalizations for Heart Failure (Annualized Rate)0.8 hospitalizations/patient-year
-40% (-0.32 hospitalizations/patient-year)
Common Side Effects
Nausea/Vomiting
+15%
Bone marrow suppression
+10%
Liver dysfunction
+7%

Clinical Trial Phases:

Phase 4