Condition

Malignant neoplasm of bone and articular cartilage

Clinical trials and treatment information for Malignant neoplasm of bone and articular cartilage

599K
People Affected
80
Active Trials
210K
New Cases/Year
66K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Surgery (Limb-Sparing Resection/Amputation)
95% Effectiveness• 95% Confidence• 50% Safety• 1000 trials• 100K participants
HIGH EvidenceExcellent Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe

Time to Effect

Immediate (tumor removal), 3-12 months for recovery/rehabilitation

Duration

Single procedure, followed by rehabilitation for months to years

Response Rate

95%

Remission Rate

90%

Common Side Effects:

Infection: 10%
Bleeding/Hematoma: 7%
Nerve damage/Neuropathy: 10%
Post-operative pain: 35%
Implant failure/Loosening (for prostheses): 7%
Loss of function/mobility: 20%

Annual Cost of Care

Drug Cost

$500

Monitoring

$15,000

Side Effects

$20,000

Total Annual

$35,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

4.5

Cost per Remission

$39,444

Cost per Responder

$37,368

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Remission Rate
+90%
Common Side Effects
Infection
+10%
Bleeding/Hematoma
+7%
Nerve damage/Neuropathy
+10%
2
Multi-agent Chemotherapy (e.g., Methotrexate, Doxorubicin, Cisplatin, Ifosfamide)
80% Effectiveness• 90% Confidence• 25% Safety• 500 trials• 50K participants
HIGH EvidenceGood ValueDose: Highly specific to regimen (e.g., Cisplatin 75-120 mg/m2, Doxorubicin 75-90 mg/m2, Methotrexate high-dose)
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe

Time to Effect

Weeks to months (during treatment cycles)

Duration

6-12 months typically

Response Rate

70%

Remission Rate

50%

Common Side Effects:

Nausea/Vomiting: 80%
Myelosuppression (low blood counts, infection risk): 90%
Fatigue: 85%
Hair Loss: 90%
Mucositis: 55%
Nephrotoxicity: 30%
Cardiotoxicity (e.g., Doxorubicin): 3%
Neurotoxicity: 20%

Annual Cost of Care

Drug Cost

$100,000

Monitoring

$20,000

Side Effects

$60,000

Total Annual

$180,000

Cost-Effectiveness

GOOD

QALYs Gained

3.5

Cost per Remission

$360,000

Cost per Responder

$257,143

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+70%
Remission Rate
+50%
Common Side Effects
Nausea/Vomiting
+80%
Myelosuppression (low blood counts, infection risk)
+90%
Fatigue
+85%

Clinical Trial Phases:

Phase 3Phase 4
3
Radiation Therapy
75% Effectiveness• 85% Confidence• 25% Safety• 300 trials• 30K participants
HIGH EvidenceGood ValueDose: 50-70 Gy in 1.8-2 Gy fractions (specific to tumor type/location)
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe

Time to Effect

Weeks to months (during and after treatment course)

Duration

4-8 weeks (daily fractions)

Response Rate

70%

Remission Rate

60%

Common Side Effects:

Fatigue: 65%
Skin reactions (redness, peeling): 80%
Nausea/Vomiting (if abdomen/pelvis involved): 35%
Mucositis (if head/neck/chest involved): 30%
Bone weakness/fracture (long term): 15%
Secondary malignancy (long term): 3%
Fibrosis of soft tissues (long term): 20%

Annual Cost of Care

Drug Cost

$200

Monitoring

$15,000

Side Effects

$10,000

Total Annual

$25,200

Cost-Effectiveness

GOOD

QALYs Gained

3

Cost per Remission

$42,000

Cost per Responder

$36,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+70%
Remission Rate
+60%
Common Side Effects
Fatigue
+65%
Skin reactions (redness, peeling)
+80%
Nausea/Vomiting (if abdomen/pelvis involved)
+35%

Clinical Trial Phases:

Phase 3Phase 4
4
High-Dose Chemotherapy with Stem Cell Rescue
65% Effectiveness• 70% Confidence• 25% Safety• 50 trials• 5K participants
MODERATE EvidencePoor ValueDose: Supra-myeloablative doses of various chemotherapeutics
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe

Time to Effect

Weeks (engraftment and initial recovery), months for full recovery

Duration

1-3 months inpatient, prolonged outpatient recovery

Response Rate

40%

Remission Rate

30%

Common Side Effects:

Profound Myelosuppression (infection, bleeding): 95%
Severe Mucositis: 80%
Organ Toxicity (cardiac, renal, hepatic): 40%
Graft-versus-host disease (allogeneic transplant): 50%
Mortality: 7%

Annual Cost of Care

Drug Cost

$75,000

Monitoring

$75,000

Side Effects

$50,000

Total Annual

$200,000

Cost-Effectiveness

POOR

QALYs Gained

2

ICER

$250,000/QALY

Cost per Remission

$666,667

Cost per Responder

$500,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+40%
Remission Rate
+30%
Common Side Effects
Profound Myelosuppression (infection, bleeding)
+95%
Severe Mucositis
+80%
Organ Toxicity (cardiac, renal, hepatic)
+40%

Clinical Trial Phases:

Phase 2Phase 3
5
Mifamurtide (Adjuvant for High-Grade Osteosarcoma, non-US approval)
55% Effectiveness• 65% Confidence• 60% Safety• 15 trials• 2K participants
MODERATE EvidencePoor ValueDose: 2 mg liposomal muramyl tripeptide intravenously
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

Months (during treatment course)

Duration

48 weeks (twice weekly for 24 weeks, then weekly for 24 weeks)

Response Rate

%

Remission Rate

%

Common Side Effects:

Fever/Chills: 50%
Fatigue: 40%
Headache: 25%
Nausea/Vomiting: 25%
Hypotension: 7%

Annual Cost of Care

Drug Cost

$120,000

Monitoring

$1,000

Side Effects

$2,000

Total Annual

$123,000

Cost-Effectiveness

POOR

QALYs Gained

0.2

ICER

$250,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+55%
Common Side Effects
Fever/Chills
+50%
Fatigue
+40%
Headache
+25%

Clinical Trial Phases:

Phase 3Phase 4
6
Immunotherapy (PD-1 Inhibitors e.g., Pembrolizumab/Nivolumab)
40% Effectiveness• 40% Confidence• 60% Safety• 20 trials• 1K participants
LOW EvidencePoor ValueDose: e.g., Pembrolizumab 200 mg IV every 3 weeks
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

1-3 months

Duration

Until progression or unacceptable toxicity (months to years)

Response Rate

15%

Remission Rate

3%

Common Side Effects:

Fatigue: 40%
Rash/Pruritus: 30%
Diarrhea/Colitis: 15%
Hypothyroidism: 10%
Pneumonitis: 3%
Other immune-related adverse events: 5%

Annual Cost of Care

Drug Cost

$180,000

Monitoring

$10,000

Side Effects

$5,000

Total Annual

$195,000

Cost-Effectiveness

POOR

QALYs Gained

0.3

ICER

$250,000/QALY

Cost per Remission

$6,500,000

Cost per Responder

$1,300,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+40%
Response Rate
+15%
Remission Rate
+3%
Common Side Effects
Fatigue
+40%
Rash/Pruritus
+30%
Diarrhea/Colitis
+15%

Clinical Trial Phases:

Phase 1Phase 2