Artemether-Lumefantrine
Treatment for Malaria
Typical Dosage: Weight-based, typically 6 doses over 3 days (e.g., 20mg artemether/120mg lumefantrine per tablet, taken twice daily)
Effectiveness
96%
Safety Score
72%
Clinical Trials
223
Participants
150K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
72
DangerousModerateSafe
Treatment Details
Dosage Range
Weight-based, typically 6 doses over 3 days (e.g., 20mg artemether/120mg lumefantrine per tablet, taken twice daily)
Time to Effect
24-48 hours
Treatment Duration
3 days
Evidence Quality
HIGHConfidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$10
Monitoring:$50
Side Effect Mgmt:$10
Total Annual:$70
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$72.9
Cost per Remission
$72.9
Comparison vs Chloroquine (in resistant areas)
Cost Difference
+$8/year
More expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Artemether-Lumefantrine Outcomes
for Malaria
Efficacy Outcomes
Overall Effectiveness
+96%
Response Rate
+96%
Remission Rate
+96%
Common Side Effects
Headache
+20%
Dizziness
+15%
Nausea/Vomiting
+10%
Abdominal pain
+10%
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
1 active trial recruiting for Artemether-Lumefantrine in Malaria
Safety and Efficacy of Imatinib in Combination With Artemether-Lumefantrine for Uncomplicated Malaria
NCT07559370RECRUITINGPHASE2
1.12K participants
INTERVENTIONAL
Kisumu, Kenya
Started: Jan 20, 2026
Completed Clinical Trials
17 completed trials for Artemether-Lumefantrine in Malaria
Evaluation of Safety and Efficacy of Artemether-Lumefantrine Tablets in African Infants and Children With Uncomplicated P. Falciparum Malaria
NCT00709969COMPLETEDPHASE3
310 participants
INTERVENTIONAL
Kilifi, Kenya +2 more
Started: Jul 1, 2002
Efficacy of Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria.
NCT02089841COMPLETEDPHASE4
140 participants
INTERVENTIONAL
Dar es Salaam, Tanzania
Started: May 1, 2012
Extended Duration Artemether-lumefantrine Treatment for Malaria in Children
NCT03453840COMPLETEDPHASE4
305 participants
INTERVENTIONAL
Busia, Uganda +1 more
Started: Feb 21, 2018
Artemether/Lumefantrine and Nevirapine Interaction Study in HIV-infected Adults
NCT00790881COMPLETEDPHASE4
36 participants
INTERVENTIONAL
Cape Town, South Africa
Started: Oct 1, 2008
Surveillance of Effectiveness/Safety of Artemether-lumefantrine in Patients With Malaria
NCT01228344COMPLETED
324 participants
OBSERVATIONAL
Atlanta, United States
Started: May 1, 2010
Lumefantrine in Venous Plasma Versus Dried Capillary Blood Spot
NCT02742285COMPLETEDPHASE4
16 participants
INTERVENTIONAL
Lausanne, Switzerland
Started: May 1, 2016
Efficacy of Antimalarial Drugs Used for the Treatment of Uncomplicated Malaria, Plasmodium Falciparum, at the Agadez, Gaya and Tessaoua Sentinel Sites
NCT05070520COMPLETEDPHASE4
259 participants
INTERVENTIONAL
Niamey, Niger
Started: Sep 1, 2020
Effectiveness of Artemether-Lumefantrine for Malaria Treatment of Children at Community Level in Tanzania
NCT00454961COMPLETEDPHASE4
200 participants
INTERVENTIONAL
Kibaha, Tanzania
Started: Apr 1, 2007
Efficacy of Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Children Under 12 Years at Four Sentinel Sites in Mozambique
NCT06970600COMPLETEDNA
352 participants
INTERVENTIONAL
Massinga, Mozambique +3 more
Started: Mar 7, 2024
TES of Artemether-lumefantrine for Pf in the Philippines in 2015
NCT05958693COMPLETED
82 participants
OBSERVATIONAL
Started: Jan 5, 2015
TES of Artemether-lumefantrine for Pf in the Philippines in 2017-2018
NCT05958810COMPLETED
80 participants
OBSERVATIONAL
Started: Jan 2, 2017
Efficacy and Safety of the Pediatric Formulation of Artemether- Lumefantrine in Children With Uncomplicated P. Falciparum Malaria.
NCT00386763COMPLETEDPHASE3
890 participants
INTERVENTIONAL
Benin, Benin +4 more
Started: Aug 1, 2006
Artemether-lumefantrine for Treatment of P. Falciparum Malaria in Brazil
NCT02600767COMPLETEDNA
79 participants
INTERVENTIONAL
Cruzeiro do Sul, Brazil
Started: Dec 1, 2015
Treatment of Uncomplicated Childhood Malaria in Tanzania by Artemether+Lumefantrine - Efficacy and Genotyping
NCT00336375COMPLETEDPHASE4
50 participants
INTERVENTIONAL
Fukayosi, Tanzania
Started: Jun 1, 2006
Artemether/Lumefantrine and Vivax Malaria
NCT01625871COMPLETEDPHASE3
38 participants
INTERVENTIONAL
Kassala, Sudan
Started: Sep 1, 2011
Randomised Efficacy Study of Two Artemether-Lumefantrine Oral Formulations for the Treatment of Uncomplicated P. Falciparum Malaria
NCT00529867COMPLETEDPHASE4
267 participants
INTERVENTIONAL
Kisumu, Kenya
Started: May 1, 2007
School-based Programme of Malaria Diagnosis and Treatment in Southern Malawi
NCT02213211COMPLETEDNA
3.67K participants
INTERVENTIONAL
Blantyre, Malawi
Started: Apr 1, 2014
Showing 20 of 231 total trials