Lubiprostone

Treatment for Irritable Bowel Syndrome

Typical Dosage: 8 mcg orally twice daily

Effectiveness
60%
Safety Score
75%
Clinical Trials
8
Participants
7K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe
Treatment Details
Dosage Range
8 mcg orally twice daily
Time to Effect
1-2 weeks
Treatment Duration
Long-term (chronic)
Evidence Quality
HIGH
Number Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
4(Treat 4 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$10,000
Monitoring:$300
Side Effect Mgmt:$250
Total Annual:$10,550
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATE
ICER
$100,000/QALY
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$37,679
Cost per Remission
$87,917
Prescription Access Economics
Annual Societal Loss per Patient
$8,110
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$250/year
Time Cost
$120/year
Travel + wait time
Insurance Admin Cost
$40/year
Prior auth, claims
Rx Price
$10,000/year
Potential OTC Price
$2,000/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOW
Missed Diagnosis Risk
MODERATE
Lubiprostone Outcomes

for Irritable Bowel Syndrome

Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+28%
Remission Rate
+12%
Common Side Effects
Nausea
+23%
Diarrhea
+13%
Abdominal pain
+8%

Sources:

nih.gov
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
6 completed trials for Lubiprostone in Irritable Bowel Syndrome

Lubiprostone Effects on Visceral Pain Sensitivity

NCT01166789COMPLETEDPHASE1
View Study
62 participants
INTERVENTIONAL
Chapel Hill, United States
Started: Feb 1, 2008

Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation

NCT00399542COMPLETEDPHASE3
View Study
581 participants
INTERVENTIONAL
Started: May 1, 2005

Intestinal Microecology in Chronic Constipation

NCT00934479COMPLETEDPHASE1
View Study
21 participants
INTERVENTIONAL
Scottsdale, United States
Started: Apr 1, 2010

Effect of Lubiprostone on Small Bowel Contractions in Female Patients With Constipation Irritable Bowel Syndrome (C-IBS)

NCT01085643COMPLETEDNA
View Study
4 participants
INTERVENTIONAL
Los Angeles, United States
Started: Mar 1, 2010

Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation

NCT00380250COMPLETEDPHASE3
View Study
590 participants
INTERVENTIONAL
Started: May 1, 2005

Effects of Lubiprostone on Gastrointestinal Transit & pH in Irritable Bowel Syndrome (IBS) With Constipation

NCT01162863COMPLETEDNA
View Study
60 participants
INTERVENTIONAL
Ann Arbor, United States
Started: Nov 1, 2010