Pentosan Polysulfate Sodium

Treatment for Interstitial Cystitis

Typical Dosage: 100mg three times daily

Effectiveness
55%
Safety Score
58%
Clinical Trials
3
Participants
5K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
58
DangerousModerateSafe
Treatment Details
Dosage Range
100mg three times daily
Time to Effect
3-6 months
Treatment Duration
Lifetime
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Confidence Score
65%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$54,000
Monitoring:$1,150
Side Effect Mgmt:$200
Total Annual:$55,350
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATE
ICER
$112,654/QALY
QALYs Gained
0.3
Outcome-Based Costs
Cost per Responder
$158,142.86
Cost per Remission
$1,107,000
Comparison vs Amitriptyline
Cost Difference
+$54,550/year
More expensive
QALY Difference
-0.20 QALYs
Worse outcomes
Dominance
No dominance
Pentosan Polysulfate Sodium Outcomes

for Interstitial Cystitis

Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+35%
Remission Rate
+5%
Common Side Effects
Nausea
+8%
Diarrhea
+7%
Alopecia
+4%
Headache
+4%
Maculopathy
+1%

Sources:

wikipedia.org
tandfonline.com
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
2 completed trials for Pentosan Polysulfate Sodium in Interstitial Cystitis

A Study of Pentosan Polysulfate Sodium and the Development of Pigmentary Maculopathy and Pigmentary Retinopathy

NCT05179460COMPLETED
View Study
2 participants
OBSERVATIONAL
Titusville, United States
Started: Oct 26, 2021

Efficacy Study of Pentosan Polysulfate Sodium,Hydrodistension and Combination Therapy for Bladder Pain Syndrome

NCT01895153COMPLETED
View Study
91 participants
OBSERVATIONAL
Seoul, South Korea
Started: Apr 1, 2012