Propylthiouracil (PTU)

Treatment for Hyperthyroidism

Typical Dosage: Initial: 100-150 mg 3 times daily; Maintenance: 50 mg 2-3 times daily

Effectiveness
80%
Safety Score
50%
Clinical Trials
2
Participants
50K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
50
DangerousModerateSafe
Treatment Details
Dosage Range
Initial: 100-150 mg 3 times daily; Maintenance: 50 mg 2-3 times daily
Time to Effect
1-2 weeks for symptom improvement, 4-8 weeks for hormone normalization
Treatment Duration
12-18 months typically, can be lifelong
Evidence Quality
HIGH
Number Needed to Harm (NNH)
750(Treat 750 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$400
Monitoring:$1,200
Side Effect Mgmt:$200
Total Annual:$1,800
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
ICER
$55,000/QALY
QALYs Gained
0.9
Outcome-Based Costs
Cost per Responder
$2,118
Cost per Remission
$4,500
Propylthiouracil (PTU) Outcomes

for Hyperthyroidism

Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+85%
Remission Rate
+40%
Common Side Effects
Rash/itching
+15%
Arthralgia/myalgia
+5%
Nausea/vomiting
+5%
Agranulocytosis
+0.5%
Severe Hepatotoxicity (can be fatal)
+0.2%

Sources:

nih.gov
researchgate.net
repec.org

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
2 completed trials for Propylthiouracil (PTU) in Hyperthyroidism

Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis

NCT05118542COMPLETEDPHASE3
View Study
36 participants
INTERVENTIONAL
Jakarta Pusat, Indonesia
Started: Jan 1, 2019

Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients

NCT02993302COMPLETEDPHASE2
View Study
25 participants
INTERVENTIONAL
Started: Jul 1, 2014