Chlorthalidone
Treatment for Hypertension
Typical Dosage: 12.5-25mg daily
Effectiveness
90%
Safety Score
70%
Clinical Trials
89
Participants
500K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
12.5-25mg daily
Time to Effect
1-3 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
30(Treat 30 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$20
Monitoring:$150
Side Effect Mgmt:$50
Total Annual:$220
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$5,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$367
Comparison vs No treatment
Cost Difference
$-220/year
Less expensive
QALY Difference
+0.50 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Chlorthalidone Outcomes
for Hypertension
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+60%
Common Side Effects
Hypokalemia
+10%
Hyperuricemia
+7%
Dizziness/Orthostatic Hypotension
+5%
Hyponatremia
+3%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
12 completed trials for Chlorthalidone in Hypertension
Efficacy and Safety of Azilsartan Medoxomil Co-Administered With Chlorthalidone in Participants With Essential Hypertension
NCT00591773COMPLETEDPHASE3
551 participants
INTERVENTIONAL
Huntsville, United States +45 more
Started: Sep 1, 2007
Pharmacogenomic Evaluation of Antihypertensive Responses 2
NCT01203852COMPLETEDPHASE4
839 participants
INTERVENTIONAL
Gainesville, United States +2 more
Started: Aug 1, 2010
Efficacy and Safety of Azilsartan Medoxomil Combined With Chlorthalidone in Participants With Moderate to Severe Hypertension
NCT00847626COMPLETEDPHASE3
1.71K participants
INTERVENTIONAL
Birmingham, United States +98 more
Started: Jan 1, 2009
Hypertension Screening and Treatment Program
NCT00007592COMPLETED
OBSERVATIONAL
Sepulveda, United States +11 more
Started: Jun 1, 1989
Ambulatory vs Office BP Management Usual Care for Diagnosing and Managing Hypertension: A Pilot Study
NCT02121041COMPLETEDNA
28 participants
INTERVENTIONAL
Chapel Hill, United States
Started: May 1, 2014
Efficacy/Safety Study of Valsartan and Chlorthalidone Conjugate Treatment Compared to Simple Treatment for Hypertension
NCT01850160COMPLETEDPHASE3
124 participants
INTERVENTIONAL
Bogota DC, Colombia +7 more
Started: Apr 1, 2013
Drug-drug Interaction Study (Telmisartan, Amlodipine, Chlorthalidone)
NCT02152969COMPLETEDPHASE1
66 participants
INTERVENTIONAL
Seoul, South Korea
Started: May 1, 2014
Chlorthalidone in Chronic Kidney Disease
NCT02841280COMPLETEDPHASE2
160 participants
INTERVENTIONAL
Indianapolis, United States
Started: Jul 1, 2016
Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults With Hypertension.
NCT06287580COMPLETEDEARLY_PHASE1
27 participants
INTERVENTIONAL
Dallas, United States
Started: Aug 15, 2024
Thiazide Diuretics for Hypertension in Kidney Transplant Recipients Using Tacrolimus
NCT02644395COMPLETEDPHASE3
49 participants
INTERVENTIONAL
Rotterdam, Netherlands
Started: Jan 18, 2013
A Pilot Study of Chlorthalidone Among Patients With Poorly Controlled Hypertension and CKD
NCT01750294COMPLETEDPHASE4
14 participants
INTERVENTIONAL
Indianapolis, United States
Started: Aug 1, 2012
Pharmacokinetic Interactions and Safety Study of Telmisartan and Chlorthalidone
NCT01806363COMPLETEDPHASE1
60 participants
INTERVENTIONAL
Daegu, South Korea
Started: Nov 1, 2012
Showing 20 of 90 total trials