Imiquimod

Treatment for HPV Infection

Typical Dosage: 3.75% or 5% cream, 3-5 times/week

Effectiveness
60%
Safety Score
72%
Clinical Trials
11
Participants
10K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
72
DangerousModerateSafe
Treatment Details
Dosage Range
3.75% or 5% cream, 3-5 times/week
Time to Effect
4-16 weeks
Treatment Duration
Up to 16 weeks
Evidence Quality
HIGH
Number Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$1,200
Monitoring:$300
Side Effect Mgmt:$100
Total Annual:$1,600
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
QALYs Gained
Outcome-Based Costs
Cost per Responder
$2,667
Cost per Remission
$2,667
Comparison vs Cryotherapy
Cost Difference
+$200/year
More expensive
QALY Difference
0.00 QALYs
Same outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$1,250
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$312.5/year
Time Cost
$87.5/year
Travel + wait time
Insurance Admin Cost
$50/year
Prior auth, claims
Rx Price
$1,200/year
Potential OTC Price
$400/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOW
Missed Diagnosis Risk
LOW
Imiquimod Outcomes

for HPV Infection

Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+60%
Remission Rate
+60%
Common Side Effects
Local erythema
+70%
Erosion
+40%
Itching
+30%
Burning
+20%
Flu-like symptoms
+7%

Sources:

nih.gov
mdpi.com
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

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Active Clinical Trials
2 active trials recruiting for Imiquimod in HPV Infection

HPV Vaccine, Imiquimod, and Metformin Combination Trial

NCT06686043RECRUITINGPHASE2
View Study
85 participants
INTERVENTIONAL
Houston, United States +1 more
Started: Aug 23, 2024

Combination Therapy of Imiquimod 5%Cream and Cryotherapy vs Monotherapy for Common Warts:Randomized Comparative Trial.

NCT06973473NOT YET RECRUITING
View Study
60 participants
OBSERVATIONAL
Started: Jul 1, 2025
Completed Clinical Trials
7 completed trials for Imiquimod in HPV Infection

Phase II Study of HPV Therapeutic Vaccine in HPV Infected Women With Normal Cytology or ASCUS/LSIL

NCT01957878COMPLETEDPHASE2
View Study
239 participants
INTERVENTIONAL
Tienen, Belgium +39 more
Started: Dec 1, 2013

Safety and Effectiveness Study of Imiquimod Creams in the Treatment of External Genital Warts

NCT00674739COMPLETEDPHASE3
View Study
470 participants
INTERVENTIONAL
Mobile, United States +29 more
Started: May 1, 2008

Efficacy and Tolerability of Topical LFX453 for External Genital Warts

NCT02482428COMPLETEDPHASE2
View Study
88 participants
INTERVENTIONAL
Arlington Heights, United States
Started: May 12, 2015

Phase 3 Study of Imiquimod Creams in the Treatment of External Genital Warts

NCT00735462COMPLETEDPHASE3
View Study
511 participants
INTERVENTIONAL
Jonesboro, United States +42 more
Started: Aug 1, 2008

Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions

NCT02135419COMPLETEDPHASE3
View Study
4.45K participants
INTERVENTIONAL
Los Angeles, United States +24 more
Started: Sep 24, 2014

Imiquimod 5% Cream in the Treatment of External Genital or Perianal Warts in HIV+ Patients

NCT00761371COMPLETEDPHASE4
View Study
52 participants
INTERVENTIONAL
Brussels, Belgium +17 more
Started: Aug 1, 2002

Study of Imiquimod Cream Prior to Ablative Therapy in External Ano-Genital Warts

NCT00189293COMPLETEDPHASE4
View Study
128 participants
INTERVENTIONAL
Ancona, Italy +11 more
Started: Jun 1, 2005