Condition

HIV/AIDS - Multidrug-resistant Tuberculosis without extensive drug resistance

Clinical trials and treatment information for HIV/AIDS - Multidrug-resistant Tuberculosis without extensive drug resistance

71K
People Affected
50
Active Trials
30K
New Cases/Year
17K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
BPaL Regimen (Bedaquiline, Pretomanid, Linezolid)
90% Effectiveness• 88% Confidence• 58% Safety• 15 trials• 1.5K participants
HIGH EvidenceExcellent ValueDose: Bedaquiline: 400mg daily for 2 weeks, then 200mg 3x/week for 22 weeks; Pretomanid: 200mg daily for 26 weeks; Linezolid: 300-600mg daily for 26 weeks
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
58
DangerousModerateSafe

Time to Effect

1-2 months for significant clinical improvement

Duration

6 months

Response Rate

90%

Remission Rate

90%

Number Needed to Treat (NNT)

2.5

Number Needed to Harm (NNH)

7

Common Side Effects:

Peripheral neuropathy: 60%
Myelosuppression (anemia, thrombocytopenia): 15%
QT prolongation: 8%
Optic neuropathy: 6%
Nausea/vomiting: 18%

Annual Cost of Care

Drug Cost

$40,000

Monitoring

$3,500

Side Effects

$3,000

Total Annual

$46,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

12

ICER

$45,000/QALY

Cost per Remission

$51,667

Cost per Responder

$51,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+90%
Common Side Effects
Peripheral neuropathy
+60%
Myelosuppression (anemia, thrombocytopenia)
+15%
QT prolongation
+8%

Clinical Trial Phases:

Phase 3Phase 4
2
Bedaquiline (as part of a longer oral regimen)
80% Effectiveness• 85% Confidence• 65% Safety• 30 trials• 5K participants
HIGH EvidenceGood ValueDose: 400mg daily for 2 weeks, then 200mg three times a week for 22 weeks
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

2-3 months for significant clinical improvement

Duration

Bedaquiline component 6-9 months, total regimen 9-18 months

Response Rate

80%

Remission Rate

80%

Number Needed to Treat (NNT)

7

Number Needed to Harm (NNH)

25

Common Side Effects:

QT prolongation: 10%
Nausea/vomiting: 15%
Hepatotoxicity: 3%
Arthralgia: 7%

Annual Cost of Care

Drug Cost

$45,000

Monitoring

$4,000

Side Effects

$3,000

Total Annual

$52,000

Cost-Effectiveness

GOOD

QALYs Gained

10

ICER

$50,000/QALY

Cost per Remission

$65,000

Cost per Responder

$65,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+80%
Remission Rate
+80%
Common Side Effects
QT prolongation
+10%
Nausea/vomiting
+15%
Hepatotoxicity
+3%

Clinical Trial Phases:

Phase 3Phase 4
3
Delamanid (as part of a longer oral regimen)
75% Effectiveness• 82% Confidence• 65% Safety• 25 trials• 4K participants
HIGH EvidenceGood ValueDose: 100mg twice daily for 24 weeks
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

2-3 months for significant clinical improvement

Duration

Delamanid component 6-9 months, total regimen 9-18 months

Response Rate

75%

Remission Rate

75%

Number Needed to Treat (NNT)

8

Number Needed to Harm (NNH)

25

Common Side Effects:

QT prolongation: 10%
Headache: 20%
Nausea: 12%
Peripheral neuropathy: 7%

Annual Cost of Care

Drug Cost

$40,000

Monitoring

$4,000

Side Effects

$2,500

Total Annual

$46,500

Cost-Effectiveness

GOOD

QALYs Gained

9

ICER

$60,000/QALY

Cost per Remission

$62,000

Cost per Responder

$62,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+75%
Remission Rate
+75%
Common Side Effects
QT prolongation
+10%
Headache
+20%
Nausea
+12%

Clinical Trial Phases:

Phase 3Phase 4
4
Linezolid (as part of an optimized background regimen for MDR-TB)
75% Effectiveness• 85% Confidence• 50% Safety• 50 trials• 10K participants
HIGH EvidenceGood ValueDose: 300-600mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe

Time to Effect

1-2 months for significant clinical improvement

Duration

Linezolid component 6-12 months, total regimen 9-18 months

Response Rate

75%

Remission Rate

75%

Number Needed to Treat (NNT)

7

Number Needed to Harm (NNH)

5

Common Side Effects:

Peripheral neuropathy: 60%
Myelosuppression (anemia, thrombocytopenia): 20%
Optic neuropathy: 7%
Nausea/vomiting: 15%

Annual Cost of Care

Drug Cost

$15,000

Monitoring

$6,000

Side Effects

$5,000

Total Annual

$26,000

Cost-Effectiveness

GOOD

QALYs Gained

8

ICER

$70,000/QALY

Cost per Remission

$34,667

Cost per Responder

$34,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+75%
Remission Rate
+75%
Common Side Effects
Peripheral neuropathy
+60%
Myelosuppression (anemia, thrombocytopenia)
+20%
Optic neuropathy
+7%

Clinical Trial Phases:

Phase 3Phase 4
5
Clofazimine (as part of an optimized background regimen for MDR-TB)
70% Effectiveness• 78% Confidence• 70% Safety• 40 trials• 7K participants
MODERATE EvidenceExcellent ValueDose: 100-200mg daily or thrice weekly
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

2-4 months for clinical improvement

Duration

Clofazimine component 6-12 months, total regimen 9-18 months

Response Rate

70%

Remission Rate

70%

Number Needed to Treat (NNT)

12

Number Needed to Harm (NNH)

15

Common Side Effects:

Skin discoloration (reddish-brown to black): 80%
Ichthyosis/dry skin: 40%
Nausea, abdominal pain, diarrhea: 20%
QT prolongation: 3%

Annual Cost of Care

Drug Cost

$12,000

Monitoring

$2,000

Side Effects

$1,000

Total Annual

$15,000

Cost-Effectiveness

EXCELLENT

QALYs Gained

7

ICER

$30,000/QALY

Cost per Remission

$21,429

Cost per Responder

$21,429

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+70%
Remission Rate
+70%
Common Side Effects
Skin discoloration (reddish-brown to black)
+80%
Ichthyosis/dry skin
+40%
Nausea, abdominal pain, diarrhea
+20%

Clinical Trial Phases:

Phase 4
6
Ethambutol (as part of an optimized background regimen for MDR-TB)
65% Effectiveness• 75% Confidence• 70% Safety• 60 trials• 12K participants
MODERATE EvidenceExcellent ValueDose: 15-25mg/kg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

2-4 months for clinical improvement

Duration

Ethambutol component 6-12 months, total regimen 9-18 months

Response Rate

65%

Remission Rate

65%

Number Needed to Harm (NNH)

30

Common Side Effects:

Optic neuritis (decreased visual acuity, red-green color blindness): 3%
Hyperuricemia: 15%
Peripheral neuropathy: 0.5%

Annual Cost of Care

Drug Cost

$11,000

Monitoring

$1,000

Side Effects

$500

Total Annual

$12,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

6

ICER

$15,000/QALY

Cost per Remission

$19,231

Cost per Responder

$19,231

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+65%
Remission Rate
+65%
Common Side Effects
Optic neuritis (decreased visual acuity, red-green color blindness)
+3%
Hyperuricemia
+15%
Peripheral neuropathy
+0.5%

Clinical Trial Phases:

Phase 4