Desmopressin (DDAVP)

Treatment for Hemophilia

Typical Dosage: 0.3 mcg/kg IV or SC, or 150-300 mcg nasally; Max 2-3 doses in 24 hours

Effectiveness
70%
Safety Score
72%
Clinical Trials
8
Participants
5K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
72
DangerousModerateSafe
Treatment Details
Dosage Range
0.3 mcg/kg IV or SC, or 150-300 mcg nasally; Max 2-3 doses in 24 hours
Time to Effect
immediate to 1 hour
Treatment Duration
acute treatment
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$1,500
Monitoring:$200
Side Effect Mgmt:$300
Total Annual:$2,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$10,000/QALY
QALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$2,666.67
Comparison vs Recombinant Factor VIII (for mild HA)
Cost Difference
$-300,000/year
Less expensive
QALY Difference
0.00 QALYs
Same outcomes
Dominance
DOMINATESBetter + cheaper
Prescription Access Economics
Annual Societal Loss per Patient
$1,350
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$250/year
Time Cost
$60/year
Travel + wait time
Insurance Admin Cost
$40/year
Prior auth, claims
Rx Price
$1,500/year
Potential OTC Price
$500/year
Estimated if OTC available
Early Treatment Benefit
+0.00 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
MODERATE
Missed Diagnosis Risk
LOW
Requires Monitoring
Yes
Needs lab work/checkups
Desmopressin (DDAVP) Outcomes

for Hemophilia

Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+75%
Common Side Effects
Facial flushing
+35%
Headache
+20%
Hyponatremia
+8%
Dizziness
+8%

Sources:

nih.gov
hemophilianewstoday.com
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
5 completed trials for Desmopressin (DDAVP) in Hemophilia

Characterization of Laboratory Response to DDAVP in Adult Hemophilia A Carriers

NCT02506023COMPLETEDPHASE1
View Study
2 participants
INTERVENTIONAL
Atlanta, United States +1 more
Started: Jul 1, 2015

Exercise Versus DDAVP in Patients With Mild Hemophilia A

NCT03379974COMPLETEDPHASE4
View Study
32 participants
INTERVENTIONAL
Indianapolis, United States +3 more
Started: Jul 31, 2018

Efficacy and Safety of IL-11 in DDAVP Unresponsive

NCT00994929COMPLETEDPHASE2
View Study
9 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Jan 1, 2010

Genetic Factors of the Desmopressin Response in Carriers of Hemophilia A

NCT06020456COMPLETED
View Study
361 participants
OBSERVATIONAL
Bordeaux, France +11 more
Started: Jan 1, 2022

Non Substitutive Strategies to Improve Haemophilia Care in Developing Countries. Experience in Ivory Coast.

NCT03054662COMPLETEDNA
View Study
142 participants
INTERVENTIONAL
Abidjan, Côte d’Ivoire
Started: Jan 16, 2017