Transoral Incisionless Fundoplication (TIF)

Treatment for GERD

Effectiveness

68%

Safety Score

60%

Clinical Trials

Participants

Comparative Safety Scale(Higher is safer)

Cyanide☠️

Meth💀

Cigarettes🚬

Chemo☢️

Alcohol🍺

Morphine💊

Antibiotics💉

Tylenol💊

Exercise🏃

Water💧

DangerousModerateSafe

Treatment Details

Time to Effect

Weeks for full post-operative recovery

Treatment Duration

One-time procedure

Evidence Quality

MODERATE

Number Needed to Treat (NNT)

4(Treat 4 patients to see 1 additional successful outcome)

Number Needed to Harm (NNH)

100(Treat 100 patients to see 1 additional serious adverse event)

Confidence Score

80%confidence in effectiveness data

Health Economics

Annual Cost of Care

Drug Cost:$0

Monitoring:$150

Side Effect Mgmt:$150

Total Annual:$2,300

Cost-Effectiveness Analysis

Cost-Effectiveness Rating

GOOD

ICER

$55,000/QALY

QALYs Gained

0.15

Outcome-Based Costs

Cost per Responder

$3,538.46

Cost per Remission

$4,600

Comparison vs Omeprazole (lifetime therapy)

Cost Difference

+$2,070/year

More expensive

QALY Difference

+0.07 QALYs

Better outcomes

Dominance

No dominance

Transoral Incisionless Fundoplication (TIF) Outcomes

for GERD

Efficacy Outcomes

Overall Effectiveness

+68%

Response Rate

+65%

Remission Rate

+50%

Common Side Effects

Dysphagia (transient)

+20%

Sore throat

+15%

Chest pain

+10%

Abdominal pain

+5%

Perforation

+0.1%

Sources:

nih.gov

semanticscholar.org

nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials

3 active trials recruiting for Transoral Incisionless Fundoplication (TIF) in GERD

Observational Registry of Transoral Incisionless Fundoplication (TIF) for Gastroesophageal Reflux Disease (GERD)

NCT05066594RECRUITING

View Study

100 participants

OBSERVATIONAL

Milan, Italy

Started: May 1, 2021

European TIF2.0 Registry

NCT07395219ENROLLING BY INVITATION

View Study

500 participants

OBSERVATIONAL

Vienna, Austria +6 more

Started: Jan 1, 2023

Transoral Incisionless Fundoplication Database Repository (TIF)

NCT04306380ENROLLING BY INVITATION

View Study

500 participants

OBSERVATIONAL

Indianapolis, United States

Started: May 20, 2020

Completed Clinical Trials

6 completed trials for Transoral Incisionless Fundoplication (TIF) in GERD