Citalopram
Treatment for Frontotemporal Dementia
Typical Dosage: 10-40mg daily (max 20mg in elderly)
Effectiveness
55%
Safety Score
58%
Clinical Trials
1
Participants
500
Comparative Safety Scale(Higher is safer)
Cyanideβ οΈ
Methπ
Cigarettesπ¬
Chemoβ’οΈ
AlcoholπΊ
Morphineπ
Antibioticsπ
Tylenolπ
Exerciseπ
Waterπ§
58
DangerousModerateSafe
Treatment Details
Dosage Range
10-40mg daily (max 20mg in elderly)
Time to Effect
4-6 weeks
Treatment Duration
Lifetime
Evidence Quality
MODERATENumber Needed to Treat (NNT)
12(Treat 12 patients to see 1 additional successful outcome)
Confidence Score
60%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$35
Monitoring:$75
Side Effect Mgmt:$20
Total Annual:$130
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$288.89
Citalopram Outcomes
for Frontotemporal Dementia
Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+45%
Common Side Effects
Nausea
+25%
Insomnia/Somnolence
+15%
Dry mouth
+12%
Sexual dysfunction
+18%
QTc prolongation
+1%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
1 completed trial for Citalopram in Frontotemporal Dementia
Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia
NCT00376051COMPLETEDPHASE4
22 participants
INTERVENTIONAL
Toronto, Canada +1 more
Started: Sep 1, 2006