Ethionamide / Prothionamide (as part of regimens)
Treatment for Extensively drug-resistant tuberculosis
Typical Dosage: 250-1000mg daily
Effectiveness
60%
Safety Score
45%
Clinical Trials
20
Participants
1.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe
Treatment Details
Dosage Range
250-1000mg daily
Time to Effect
3-6 months
Treatment Duration
18-24 months
Evidence Quality
LOWConfidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$250
Monitoring:$1,500
Side Effect Mgmt:$1,500
Total Annual:$3,250
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$50,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$5,417
Cost per Remission
$5,417
Comparison vs Less effective older XDR-TB regimens
Cost Difference
$-500/year
Less expensive
QALY Difference
+0.20 QALYs
Better outcomes
Dominance
No dominance
Ethionamide / Prothionamide (as part of regimens) Outcomes
for Extensively drug-resistant tuberculosis
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+60%
Remission Rate
+60%
Common Side Effects
Gastrointestinal intolerance
+60%
Hepatotoxicity
+15%
Psychiatric disturbances (depression, psychosis)
+12%
Peripheral neuropathy
+15%
Hypothyroidism
+7%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov