Insulin Therapy (Basal-Bolus Regimen)
Treatment for Diabetes mellitus type 1
Typical Dosage: Highly individualized, typically 0.4-1.0 units/kg/day
Effectiveness
95%
Safety Score
55%
Clinical Trials
21
Participants
2M
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
Highly individualized, typically 0.4-1.0 units/kg/day
Time to Effect
Immediate for acute effects, weeks-months for stable control
Treatment Duration
Lifetime
Evidence Quality
HIGHConfidence Score
98%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$5,000
Monitoring:$1,500
Side Effect Mgmt:$500
Total Annual:$7,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
20
Outcome-Based Costs
Cost per Responder
$7,778
Insulin Therapy (Basal-Bolus Regimen) Outcomes
for Diabetes mellitus type 1
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+90%
Common Side Effects
Hypoglycemia
+60%
Weight Gain
+30%
Lipohypertrophy
+25%
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
18 completed trials for Insulin Therapy (Basal-Bolus Regimen) in Diabetes mellitus type 1
baSal BoluS Therapy in patIenTs With TypE 1 Diabetes Mellitus
NCT01204593COMPLETEDPHASE4
206 participants
INTERVENTIONAL
Algeries, Algeria +42 more
Started: Nov 1, 2010
Clinical Trial of Efficacy and Safety of Subetta in the Combined Treatment of Patients With Type I Diabetes Mellitus
NCT01868594COMPLETEDPHASE4
200 participants
INTERVENTIONAL
Moscow, Russia +14 more
Started: May 7, 2013
Comparison of NN1250 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetes
NCT01074268COMPLETEDPHASE3
456 participants
INTERVENTIONAL
Caba, Argentina +68 more
Started: Feb 1, 2010
The Effect of Exercise on Blood Glucose Levels in Patients With Type 1 Diabetes: A Comparison of 3 Long-acting Insulins
NCT00313742COMPLETEDPHASE4
51 participants
INTERVENTIONAL
Neuss, Germany +1 more
Started: Apr 1, 2006
Examining the Long-term Safety of Insulin Aspart When Used as a Part of the Treatment for Type 1 Diabetes
NCT00832182COMPLETEDPHASE3
75 participants
INTERVENTIONAL
Zagreb, Croatia +9 more
Started: Dec 22, 1999
Apidra Children & Adolescents Study
NCT01202474COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Moscow, Russia
Started: May 1, 2011
Safety Follow-up on Children and Adolescents With Type 1 Diabetes Treated With Insulin Detemir. An Extension to Trial NN304-1689
NCT00623194COMPLETEDPHASE3
146 participants
INTERVENTIONAL
Pleven, Bulgaria +31 more
Started: Feb 1, 2008
A Trial Investigating the Pharmacokinetic and Pharmacodynamic Properties of FIAsp When Administered as a Bolus in a Continuous Subcutaneous Infusion Regimen in Subjects With Type 1 Diabetes
NCT01992588COMPLETEDPHASE1
48 participants
INTERVENTIONAL
Neuss, Germany
Started: Nov 1, 2013
Variable Bolus Regimen 1-2-3 for Type 2 Diabetes Mellitus
NCT00135083COMPLETEDPHASE3
347 participants
INTERVENTIONAL
Started: Aug 1, 2004
Frequency of Hypoglycaemic Episodes During Treatment With Insulin Detemir in Well Controlled Subjects With Type 1 Diabetes
NCT01697657COMPLETEDPHASE3
131 participants
INTERVENTIONAL
Camperdown, Australia +10 more
Started: Sep 1, 2001
Effect of Fiasp® in Type 1 Diabetes Treatment
NCT03895515COMPLETED
178 participants
OBSERVATIONAL
Stockholm, Sweden
Started: Jan 3, 2020
Observational Study of Type 1 Diabetics Switching From Human Insulins to Modern Insulin Analogues
NCT00873639COMPLETED
417 participants
OBSERVATIONAL
Bucharest, Romania
Started: Apr 1, 2009
Personalized Glucose Predictive and Therapy Advisory System - DIAdvisor 2
NCT01512654COMPLETEDNA
60 participants
INTERVENTIONAL
Prague, Czechia +2 more
Started: Sep 1, 2008
Intensive Insulin Treatment and Ischemic Foot Ulcer
NCT01957930COMPLETEDNA
91 participants
INTERVENTIONAL
Stockholm, Sweden +1 more
Started: Jan 1, 1984
Canadian Real-World Outcomes of Omnipod Initiation in People With T1D
NCT04226378COMPLETED
286 participants
OBSERVATIONAL
Toronto, Canada
Started: Jan 20, 2020
Albiglutide Versus Placebo in Insulin-treated Subjects With New-onset Type 1 Diabetes Mellitus
NCT02284009COMPLETEDPHASE2
67 participants
INTERVENTIONAL
Bois-Guillaume, France +31 more
Started: Oct 10, 2014
Use of Continuous Glucose Sensors by Adolescents With Inadequate Diabetic Control
NCT00945659COMPLETEDNA
116 participants
INTERVENTIONAL
Jacksonville, United States
Started: Aug 1, 2009
Feasibility of a Decision Support System to Reduce Glucose Variability in Subject With T1DM
NCT02558491COMPLETEDNA
33 participants
INTERVENTIONAL
Charlottesville, United States
Started: Sep 1, 2015
Showing 20 of 21 total trials