Condition

Chlamydia

Common bacterial sexually transmitted infection

152.2M
People Affected
17
Active Trials
235.7M
New Cases/Year
1,033
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Azithromycin
97% Effectiveness• 95% Confidence• 70% Safety• 49 trials• 75K participants
HIGH EvidenceExcellent ValueDose: 1 gram orally as a single dose
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

3-7 days

Duration

Single dose

Response Rate

97%

Remission Rate

97%

Number Needed to Treat (NNT)

1

Number Needed to Harm (NNH)

10

Common Side Effects:

Nausea: 10%
Diarrhea: 10%
Abdominal pain: 10%
Headache: 5%

Annual Cost of Care

Drug Cost

$10

Monitoring

$75

Side Effects

$5

Total Annual

$90

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.08

ICER

$15,000/QALY

Cost per Remission

$92.78

Cost per Responder

$92.78

Treatment Outcomes
Primary Outcomes
Proportion of Individuals with Persistent Genital C. trachomatis Infection (NAAT confirmed)100% (positive NAAT at baseline)
-97% (-97 percentage points)
Chlamydia-related Symptom Severity Score (e.g., VAS for pain/dysuria in symptomatic patients)Mean score of 7/10 (Visual Analog Scale)
-86% (-6 points (on a 10-point VAS))
Severity of Genital Discharge (clinical assessment score in symptomatic patients)Moderate discharge (3/5 on a clinical severity scale)
-90% (-2.7 points (on a 5-point scale))
Secondary Benefits
Chlamydia-related Quality of Life Score (e.g., EQ-5D index)Mean score of 0.70 (EQ-5D index range 0-1)
+15% (+0.105 points (on EQ-5D index))
Anxiety Scale Score (e.g., GAD-7 in patients with infection-related distress)12/21 (moderate anxiety on GAD-7 scale)
-50% (-6 points (on GAD-7 scale))
Polymorphonuclear Leukocytes (PMLs) per High Power Field (HPF) in genital smears15 PMLs/HPF (elevated count)
-93.3% (-14 PMLs/HPF)
Common Side Effects
Nausea
+10%
Diarrhea
+10%
Abdominal pain
+10%

Clinical Trial Phases:

Phase 4
2
Doxycycline
97% Effectiveness• 95% Confidence• 70% Safety• 19 trials• 75K participants
HIGH EvidenceExcellent ValueDose: 100 mg orally twice daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

3-7 days

Duration

7 days

Response Rate

97%

Remission Rate

97%

Number Needed to Treat (NNT)

1

Number Needed to Harm (NNH)

10

Common Side Effects:

Photosensitivity: 10%
Nausea: 10%
Esophageal irritation: 5%
Diarrhea: 5%

Annual Cost of Care

Drug Cost

$7

Monitoring

$75

Side Effects

$5

Total Annual

$87

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.08

ICER

$12,000/QALY

Cost per Remission

$89.69

Cost per Responder

$89.69

Treatment Outcomes
Primary Outcomes
Proportion of Positive Chlamydia trachomatis NAAT Results100% (in initially infected cohort)
-96.5% (Reduced to ~3.5% positive results (96.5% cure rate) in the treated cohort)
Patient-reported Genital Symptom Severity (e.g., discharge, dysuria, pain)Moderate (average 6.0 on 0-10 Visual Analog Scale)
-83.3% (-5.0 points (to an average of 1.0 on 0-10 VAS scale))
Severity of Clinical Signs of Cervicitis/Urethritis (e.g., discharge, edema, friability)Moderate (average 2.0 on a 0-3 scale: 0=none, 1=mild, 2=moderate, 3=severe)
-85% (-1.7 points (to an average of 0.3 on a 0-3 scale))
Secondary Benefits
Genital Health-Related Quality of Life (QoL) ScoreImpaired (average 55/100 on a validated QoL scale)
+27.3% (+15 points (to an average of 70/100 on a validated QoL scale))
Risk of Sexual Transmission of Chlamydia trachomatis (per encounter)Elevated (in infected individuals)
-100% (Reduced to negligible levels (in cured individuals))
Leukocyte Esterase Test (in urine, as a marker of inflammation)Positive (in symptomatic urethritis/cervicitis)
-90% (Change from Positive to Negative in ~90% of cases)
Common Side Effects
Photosensitivity
+10%
Nausea
+10%
Esophageal irritation
+5%

Clinical Trial Phases:

Phase 4
3
Levofloxacin
96% Effectiveness• 85% Confidence• 65% Safety• 60 trials• 15K participants
MODERATE EvidenceGood ValueDose: 500 mg orally once daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

3-7 days

Duration

7 days

Response Rate

96%

Remission Rate

96%

Number Needed to Treat (NNT)

1

Number Needed to Harm (NNH)

20

Common Side Effects:

Nausea: 10%
Diarrhea: 10%
Headache: 5%
Dizziness: 3%
Tendon rupture: 0.1%

Annual Cost of Care

Drug Cost

$40

Monitoring

$75

Side Effects

$15

Total Annual

$130

Cost-Effectiveness

GOOD

QALYs Gained

0.07

ICER

$100,000/QALY

Cost per Remission

$135.42

Cost per Responder

$135.42

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+96%
Response Rate
+96%
Remission Rate
+96%
Common Side Effects
Nausea
+10%
Diarrhea
+10%
Headache
+5%

Clinical Trial Phases:

Phase 4