Daclatasvir + Sofosbuvir

Treatment for Acute hepatitis C

Typical Dosage: Sofosbuvir 400 mg once daily + Daclatasvir 60 mg once daily

Effectiveness
95%
Safety Score
68%
Clinical Trials
30
Participants
6K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe
Treatment Details
Dosage Range
Sofosbuvir 400 mg once daily + Daclatasvir 60 mg once daily
Time to Effect
Within 12-24 weeks of treatment completion
Treatment Duration
12 weeks
Evidence Quality
HIGH
Number Needed to Treat (NNT)
1(Treat 1 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
100(Treat 100 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$12,000
Monitoring:$1,000
Side Effect Mgmt:$200
Total Annual:$13,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
ICER
$75,000/QALY
QALYs Gained
2.5
Outcome-Based Costs
Cost per Responder
$13,895
Cost per Remission
$13,895
Comparison vs Pegylated Interferon + Ribavirin
Cost Difference
$-21,800/year
Less expensive
QALY Difference
+2.00 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Daclatasvir + Sofosbuvir Outcomes

for Acute hepatitis C

Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Remission Rate
+95%
Common Side Effects
Headache
+18%
Fatigue
+12%
Nausea
+7%
Diarrhea
+4%

Sources:

nih.gov
oup.com
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov